摘要
目的探讨中性粒细胞与淋巴细胞比值(NLR)与早期糖尿病肾病(DN)的相关性。方法回顾性分析2016年3月至2017年6月132例糖尿病(DM)患者,依据Mogensen分类标准分为DN组、早期DN组和无肾病DM组,并选取60例门诊体检的健康者为对照组,对比NLR在各组之间的差异,分析NLR与早期DN的相关性,Logistic回归分析早期DN的危险指标。结果 NLR在早期DN组患者中显著高于无肾病DM组和对照组,差异有统计学意义(P<0.05);NLR与早期DN呈正相关(r=0.668,P<0.05);NLR是早期DN的危险因素[OR=6.97(95%CI:6.294～53.842),P=0.001]。结论 NLR与早期DN的发生有密切关系,且可以作为糖尿病早期肾功能损害的有效指标。
Objective To investigate the correlation between the ratio of neutrophils to lymphocyte （NLR） and early diabetic nephropathy （DN）. Methods We retrospective included in the March 2016-2017 year in June 132 cases of diabetes mellitus （DM） patients,according to the Mogensen classification criteria were divided into DN group,DN group and non DM early nephropathy group,and randomly selected 60 cases of physical examination of normal control （NLR）,compared the difference among the groups,correlation analysis of NLR and DN in early stage.Logistic regression analysis of risk index of early DN. Results The NLR in early DN patients without nephropathy was significantly higher than that of DM group and control group,the difference was statistically significant （ P 〈0.05）;NLR and early DN highly positive correlation exists （ r =0.668, P 〈 0.05 ）;NLR is a risk factor for early [ OR =6.97 （95% CI ：6.294-53.842）, P =0.001]. Conclusion The early occurrence of DN in NLR has a close relationship,and it can be used as an effective indicator of renal impairment in early diabetes.
作者
王爱兰
倪永圣
何思杰
晏文芬
黄翠芳
汤敏娟
WANG Ailan;NI Yongsheng;HE Sijie;YAN Wenfen;HUANG Cuifang;TANG Minjuan(Department of Endocrinology,Nanhai Hospital,Southern Medical University,Foshan,Guangdong 528244,China)
出处
《检验医学与临床》
CAS
2018年第22期3342-3344,3348,共4页
Laboratory Medicine and Clinic
基金
广东省佛山市科技计划项目(2016AB000882)
