摘要
目的:探讨多种标记物联合应用对前列腺癌诊断的临床意义?厱方法:选择我院入住均经血清PSA检测初步判定为前列腺癌患者117例,为确诊将患者平均分为3组,各39例,通过与病理诊断结果比较3组患者前列腺癌的诊断准确度。结果:A组患者检测率与病理诊断结果相比较符合率为77.2%,B组为90.3%,C组为98.2%,A、B两组均低C组,且B组高于A组,表明P504s检测诊断率高于P63、CK34βE12检测,且联合检测诊断率最高。3组患者比较差异均有统计学意义(P<0.05)。A组13例良性标本中,阴性10例,假阳性3例,符合率为76.9%,B组12例良性标本中,阴性11例,假阳性1例,符合率为91.7%,C组11例良性标本中,阴性11例,假阳性0例,符合率为100%?厱联合检测的假阳性诊断率明显低于A、B两组患者,3组患者比较差异均有统计学意义(P<0.05)。A组在26例前列腺癌中,阳性22例,漏诊4例,符合率为84.6%。B组在27例前列腺癌中,阳性25例,漏诊2例,符合率为92.6%,C组在27例前列腺癌中,阳性26例,漏诊1例,符合率为96.3%。3组患者比较差异均有统计学意义(P <0.05)。结论:联合使用P504s(AMACR)?厲基底细胞特异性标记物(P63和CK34βE12)检测诊断可以明显提高前列腺癌的早期诊断率,对临床有重要意义。
Objective： To explore the combined application of multiple markers for diagnosis of prostate cancer. Method： To choose the hospital in September, 2012 to September 2015, initially determined both by serum PSA test for prostate cancer patients 117 cases, for patients with confirmed will be divided into three groups （39 cases further examination, compared with the pathological diagnosis of three groups of patients with prostate cancer diagnosis accuracy.Results The detection rate in group A patients compared with the pathological diagnosis coincidence rate was 77.2%, B group was 90.3%, and 98.2% of group C, A, B two groups were lower in group C, group A and group B was higher than that that P504s inspection diagnosis rate is higher than about, CK34 beta E12 at 11：45, joint detection and diagnosis rate is highest.Three groups of patients were compared with difference had statistical significance （ P 〈0.05）.A group of 13 cases of benign specimen, 10 cases were negative, false positive in 3, coincidence rate was 76.9%, B group of 12 cases of benign specimens, the negative in 11 cases, false positives in 1 case, the coincidence rate is 91.7%, group C of 11 cases of benign specimens, negative in 11 cases, false positive 0 cases, coincidence rate was 100%. Combined detection of false positive diagnosis rate was lower than that in group A, B two patients, three groups of patients were compared with difference had statistical significance （ P 〈0.05）.Group A in 26 cases of prostate cancer, positive 22 cases, 4 cases were missed diagnosis coincidence rate was 84.6%. Group B in 27 cases of prostate cancer, positive 25 cases, 2 cases of misdiagnosis, the coincidence rate is 92.6%, group C in 27 cases of prostate cancer, 26 patients, positive, 1 case of misdiagnosis, the coincidence rate was 96.3%. Three groups of patients were compared with difference had statistical significance （ P 〈0.05）.Conclusion Combination of P504s （AMACR）, basal cell specific markers （about and CK34 beta E12 at 11：45） detection diagnosis can improve the early diagnostic rate of prostate cancer, have important significance on clinical.
作者
辛华
王莉
张淑萍
张文陆
牟洪香
江清林
XIN Hua;WANG Li;ZHANG Shu-ping;ZHANG Wen-lu;MU Hong-xiang;JIANG Qing-lin(the First Affiliated Hospital of Jiamusi University,Heilongjiang,Jiamusi 154003,China)
出处
《海南医学院学报》
CAS
2018年第20期1849-1851,共3页
Journal of Hainan Medical University
基金
黑龙江省自然科学基金项目(D201225)
佳木斯大学科学技术重点项目(12Z1201504)~~
