摘要
目的探讨小儿慢性咳嗽采用普米克令舒联合孟鲁司特治疗的临床疗效。方法随机选取2015年10月至2017年10月收治的80例慢性咳嗽患儿作为研究对象,采用入院单双号法将其分为对照组(40例)和观察组(40例),对照组患儿给予盐酸丙卡特罗片和酮替芬片进行治疗,观察组患儿口服普米克令舒联合孟鲁司特进行治疗。对比两组患儿的临床疗效、治疗前、后呼吸功能指标水平以及不良反应发生情况。结果观察组患儿的临床治疗总有效率为95.00%,显著高于对照组的77.50%,差异具有统计学意义(P<0.05)。治疗后,两组的PaO_2、a/APO_2、pH水平均显著升高,PaCO_2及OI水平均显著降低,且观察组均明显优于对照组,差异具有统计学意义(P<0.05)。观察组患儿的头疼、眩晕、口干、乏力、恶心、腹部不适等不良反应总发生率为7.50%,明显低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论普米克令舒联合孟鲁司特治疗小儿慢性咳嗽效果显著,能够有效改善患儿气道炎症,缓解咳嗽症状,治疗方法简单,值得临床推广与应用。
Objective To investigate clinical efficacy of pulmicort respules combined with montelukast in the treatment of chronic cough in children. Methods Eighty children with chronic cough from October 2015 to October 2017 were randomly selected as the study objects and divided into control group （40 cases） and observation group （40 cases） by single and double admission method. The control group was given procaterol hydrochloride tablets and ketotifen tablets for treatment, while the observation group was given pulmicort respules combined with montelukast for treatment. The clinical efficacy, levels of respiratory function indexes before and after treatment and the incidences of adverse reactions of the two groups were compared. Results The total effective rate of treatment in the observation group was 95.00%, which was significantly higher than 77.50% in the control group, the difference was statistically significant （P〈0.05）. After treatment, the levels of PaO2, a/APO2 and pH in the two groups significantly increased, while the levels of PaCO2 and OI significantly decreased, and those in the observation group were significantly better than the control group, and the differences were statistically significant （P〈0.05）. The total incidence of headache, vertigo, dry mouth, fatigue, nausea and abdominal discomfort in the observation group was 7.50%, which was significantly lower than 20.00% in the control group, the difference was statistically significant （P〈0.05）. Conclusion Pulmicort respules combined with montelukast in the treatment of chronic cough in children has a significant effect, which can effectively improve airway inflammation of children, relieve cough symptoms. It is simple and worthy of clinical promotion and application.
作者
王红利
王瑞阳
WANG Hong-li;WANG Rui-yang(the Hospital of Pucheng County,Weinan 715500;Maternal and Child Health Care Hospital of Fuping County,Weinan 711700,China)
出处
《临床医学研究与实践》
2018年第31期100-102,共3页
Clinical Research and Practice
关键词
小儿慢性咳嗽
普米克令舒
孟鲁司特
chronic cough in children
pulmicort respules
montelukast
