摘要
目的探讨晚餐后服用盐酸二甲双胍缓释片对次日清晨空腹血糖的影响。方法选择2015年6月至2017年6月在我院内分泌科就诊的2型糖尿病患者80例为研究对象,患者年龄为(45±16)岁,采取奇数偶数随机分组的方法分为对照组和观察组各40例。对照组采用吡格列酮治疗,观察组采用二甲双胍缓释片治疗。治疗12周监测患者的空腹血糖、体重、糖化血红蛋白、胰岛素水平经行评估。结果比较两组治疗前后;观察组治疗后空腹血糖、糖化血红蛋白、明显低于对照组,差异有统计学意义(P<0.05);体重、胰岛素抵抗指数差异无统计学意义(P>0.05)。结论二甲双胍缓释片在降低空腹血糖,降低糖化血红蛋白方面较吡格列酮有明显优势。
Objective to explore the effect of metformin hydrochloride on fasting blood glucose in the morning after dinner. Methods from June 2015 to June 2017 in the endocrine department of our hospital, 80 cases of type 2 diabetic patients were studied, the patients were（45±16） years old, and the methods of odd even random group were divided into control group and observation group in 40 cases. The control group was treated with pioglitazone, and the observation group was treated with metformin sustained-release tablets. Fasting blood glucose, weight, glycosylated hemoglobin and insulin levels were evaluated in patients undergoing 12-week treatment. Results before and after treatment, fasting blood glucose and hba1 c in the observation group were significantly lower than those in the control group（P〈0.05）.There was no significant difference in body weight and insulin resistance index（P〉0.05）. Conclusion metformin sustained release tablets have obvious advantages over pioglitazone in reducing fasting blood glucose and glycosylated hemoglobin.
作者
苟芳
张红军
张邱兵
张萍
GOU Fang;ZHANG Hong-jun;ZHANG Qiu-bin;ZHANG Ping(Department Of Endocrinology,Central Hospital Of Guangyuan City,Guangyuan,Sichuan,62800)
出处
《智慧健康》
2018年第27期124-125,127,共3页
Smart Healthcare
关键词
2型糖尿病
二甲双胍缓释片
吡格列酮
血糖
Type2 diabetes
Mefformin sustained release tablets
Pioglitazone
Blood sugar
