摘要
目的检测寻常型银屑病患者血清肝素酶(HPA)和血管内皮生长因子(VEGF)水平并探讨其临床意义。方法采用酶联免疫吸附法(ELISA)检测90例寻常型银屑病患者血清HPA和VEGF水平,并以60名正常人作对照。结果寻常型银屑病患者血清HPA和VEGF水平均显著高于对照组(P<0.05);进行期患者血清HPA和VEGF水平均显著高于静止期患者(P<0.05);血清HPA和VEGF水平均与银屑病皮损面积及严重程度指数(PASI)评分呈正相关(P<0.05)。结论寻常型银屑病患者血清中HPA和VEGF水平显著升高,与疾病活动和严重程度密切相关,有助于对银屑病病情的判断。
Objective In order to detect serum heparanase （HPA） and vascular endothelial growth factor （VEGF） in patients with psoriasis vulgaris and its clinical significance. Methods Serum HPA and VEGF in 90 patients with psoriasis vulgaris and 60 healthy controls were measured by enzyme linked immunosorbent assay （ELISA）. Results The serum HPA and VEGF levels in patients with psoriasis vulgaris were significantly higher than those in the control group （P〈0.05）. The serum HPA and VEGF levels in the patients with progressive psoriasis were significantly higher than those in the stationary phase （P〈0.05）,and the levels of serum HPA and VEGF were positively correlated with PASI score （P〈0.05）. Conclusion The levels of serum HPA and VEGF in patients with psoriasis vulgaris were significantly increased,closely related to the disease activity and severity,which could help to judge the condition of psoriasis.
作者
殷文浩
金梦祝
丁韧烨
Yin Wenhao;Jin Mengzhu;Ding Renye(Jiaxing First Hospital,Jiaxing 314001,China)
出处
《中国中西医结合皮肤性病学杂志》
CAS
2018年第5期395-397,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金
浙江省中医药科学研究基金项目(2015ZB114)
关键词
寻常型银屑病
肝素酶
血管内皮生长因子
Psoriasis vulgaris；Heparanase；Vascular endothelial growth factor
