摘要
目的:观察盐酸多奈哌齐联合奥拉西坦治疗老年痴呆的临床效果。方法:选取老年痴呆患者100例为研究对象,采用随机数字表法将其分为观察组和对照组各50例。对照组给予奥拉西坦治疗,观察组在对照组基础上联合盐酸多奈哌齐治疗。比较两组治疗前后的痴呆严重程度(CDR量表)、日常生活活动能力(ADL量表)、精神状态(MMSE量表)及临床疗效。结果:治疗12周后,观察组CDR量表评分明显低于对照组,ADL和MMSE量表评分均明显高于对照组,观察组治疗总有效率为94.00%(47/50),明显高于对照组的78.00%(39/50),差异均具有统计学意义(P<0.05)。观察组不良反应发生率为6.0%,低于对照组的8.0%,但差异无统计学意义(P>0.05)。结论:盐酸多奈哌齐联合奥拉西坦治疗老年痴呆,既能有效改善患者的痴呆症状和精神状态,还能显著提升其日常生活活动能力,且并未明显增加不良反应发生率。
Objective： To observe clinical efficacy of Donepezil hydrochloride combined with Oxiracetam in treatment of senile dementia. Methods： One hundred patients with senile dementia were used as the research objects. They were divided into observation group and control group by the random number table method, 50 cases in each. The patients in the control group were treated with Oxiracetam, while those in the observation group were treated with Donepezil hydrochloride based on that of the control group. The scores of the severity of dementia （CDR scale）, activities of daily living （ADL scale） and mental state （MMSE scale） as well as clinical efficacy were compared between the two groups before and after the treatment. Results： 12 weeks after the treatment, the score of the CDR scale in the observation group were significantly lower than that in the control group. The scores of the ADL and MMSE scales in the observation group were significantly higher than those of the control group. The total effective rate of the observation group was 94.00% （47/50）, which was significantly higher than that of the control group （78.00%, 39/50）, and the difference was statistically significant （P〈0.05）. The adverse reaction rate was 6.0% in the observation group, which was lower than 8.0% in the control group, but the difference was not statistically significant （P〉0.05）. Conclusions： Donepezil hydrochloride combined with Oxiracetam in the treatment of senile dementia is significantly effective. It can not only improve the symptoms and mental state of dementia, but also significantly enhance the ability of daily living activities without increasing the incidence of adverse reactions.
作者
庞润慧
PANG Runhui(The Third People＇s Hospital of Tianshui City,Tianshui Gansu 741000,China)
出处
《中国民康医学》
2018年第20期73-74,79,共3页
Medical Journal of Chinese People’s Health
关键词
老年痴呆
盐酸多奈哌齐
奥拉西坦
Senile dementia
Donepezil hydrochloride
Oxiracetam
