摘要
目的探究质子泵抑制剂的药理情况和临床应用效果。方法此文实行研究的资料为2015年6月—2017年12月本院收入的105例胃肠道溃疡患者,参考随机法分成三组,每组35例,奥美拉唑用于实验1组,泮托拉唑用于实验2组,雷贝拉唑用于实验3组,分析三组相关指标。结果实验1组治疗总有效率和实验2组、实验3组比较,差异无统计学意义(P> 0.05),实验2组不良反应发生率和实验1组、实验3组比较,差异有统计学意义(P <0.05)。结论雷贝拉唑、奥美拉唑、泮托拉唑在胃肠道溃疡治疗中均具有明确疗效,且泮托拉唑的不良反应小,推荐使用。
Objective To explore the pharmacology and clinical application of proton pump inhibitors. Methods 105 cases of gastric and intestinal ulcers in our hospital from June 2015 to December 2017 were divided into three groups, including 35 cases in each group, omeprazole was used in experimental group 1, pantoprazole was used in experimental group 2, rabeprazole was used in experimental group 3, and related indexes were analyzed. Results There was no signifcant diference in total efective rate between experimental group 1 and experimental group 2 and experimental group 3 （P 〉 0.05）. The incidence of adverse reactions in experimental group 2 was significantly higher than that in experimental group 1 and experimental group 3 （P 〈 0.05）. Conclusion The effect of rabeprazole, omeprazole and pantoprazole in the treatment of gastrointestinal ulcer is clear, and the adverse reaction of omeprazole is small.
作者
唐智权
TANG Zhiquan(Pharmacy Department,The People＇s Hospital of Rongchang District of Chongqing,Chongqing 402460,China)
出处
《中国继续医学教育》
2018年第31期107-108,共2页
China Continuing Medical Education
关键词
质子泵抑制剂
药理
不良反应
雷贝拉唑
奥美拉唑
泮托拉唑
proton pump inhibitors
pharmacology
adverse reactions
rabeprazole
omeprazole
pantoprazole
