摘要
目的探讨影响幽门螺杆菌(Helicobacter pylori,Hp)根除效果的相关因素,为临床采取干预措施提高根除率提供依据。方法经^(14)C-尿素呼气试验确诊为Hp阳性,且经胃镜检查确诊为慢性胃炎和消化性溃疡的647例患者,以12日艾普拉唑联合胶体果胶铋、阿莫西林、左氧氟沙星的四联疗法作为初次根除治疗方案,根据Hp根除结果分为根除成功组及根除失败组,采用单因素分析及二分类Logistic回归进行统计分析,分析不同因素对Hp根除率的影响。结果四联方案Hp根除率为89.5%。单因素分析发现:吸烟及依从性与Hp根除率有关,差异有统计学意义(P<0.05)。二分类Logistic回归分析发现:患者吸烟、依从性是影响Hp根除率的主要因素(P<0.05)。结论吸烟及依从性是影响Hp根除率的不利因素,可采取相应干预措施提高Hp根除率。
Objective To investigate the factors related to eradication of Helicobaeter pylori （H.Pylori） in order to improve the eradication rate of H. Pylori.Methods Six hundred and fortyseven patients with H.Pylori infection who had peptic ulcer or chronic gastritis were divided into two groups according to the H.Pylori eradication results. 12 days of Ilaprazole combined with colloidal bismuth pectin, amoxicillin, levofloxacin as the treatment prescription. Univariate analysis and logistic regression analysis were used to analyze the influence of different factors on eradication rate.Results The eradication rate of H.Pylori was 89.5% in the quadruple therapy. The univariate analysis found that there were differences in smoking and treatment compliance （P〈0.05）. The logistic regression analysis found that smoking and treatment compliance were unfavorable factors for H.Pylori eradication rate （P〈0.05）.Conclusion Smoking and treatment compliance are important factors affecting the H. Pylori eradication rate, we should take counter measures to improve the eradication rate.
出处
《中国煤炭工业医学杂志》
2017年第6期657-660,共4页
Chinese Journal of Coal Industry Medicine
基金
唐山市科技支撑计划项目(编号:14130229a)
关键词
幽门螺杆菌
根除率
不利因素
四联方案
Helicobacter pylori
Eradication rate
Unfavorable factors
Quadruple therapy
