摘要
目的探究宣郁通经汤联合黄体酮治疗先兆流产的效果，以及其对患者雌二醇（E2）、孕酮（P）及β-人绒毛膜促性腺激素（β-hCG）的影响。方法选取2014年1月-2016年10月在沈阳市第二中医医院就诊的先兆流产患者120例，随机分为对照组（n=60）和观察组（n=60），对照组给予黄体酮肌内注射治疗。观察组在对照组基础上给予宣郁通经汤加减治疗，比较两组保胎成功率，治疗前后血清E2、P、β-hCG水平，两组临床症状缓解时间、消失时间及不良反应发生情况。结果观察组保胎成功率90．00％高于对照组的73．33％，差异有统计学意义（P〈0．05）。观察组总有效率93．33％高于对照组的76．67％，差异有统计学意义（P〈0．05）。治疗后两组E2、P、β-hCG水平均有升高，观察组血清E2、P、β-hCG水平比对照组升高较多，差异有统计学意义（P〈0．05）。观察组症状缓解时间、消失时间较对照组短，差异有统计学意义（P〈0．05）。两组均未见明显的不良反应。结论宣郁通经汤加减辅助治疗先兆流产可以较快改善孕妇激素水平，缓解临床症状，提高保胎成功率且不良反应较少，值得临床进行推广应用。
Objective To investigate the effect of modified Xuanyutongjing Decoction combined with progesterone on the levels of estradiol （E2）, progesterone （P） and β-human chorionic gonadotropin （β-hCG） in patients with threatened abortion. Methods Between January 2014 to October 2016, a total of 120 patients with threatened abortion in our hospital were selected and randomly divided into observation group and control group （60 cases in each group）. The patients in control group were treated with simple progesterone, and the patients in observation group adopted modified Xuanyutongjing Decoction combined with progesterone. The pregnancy survival rate, the levels of E2, P, and β-hCG, remission time and disappearance time of clinical symptom, and the incidence of adverse reactions were compared between two groups. Results The pregnancy survival rate in observation group （90%） was significantly higher than control group （73.33%） （P〈0.05）. The total effective rate in observation group was significantly higher than control group （93.33% vs 76.67%, P〈0.05）. The serum E2, P, and β-hCG levels increased after treatment, and elevation degrees in observation group were significantly higher than control group （P〈0.05）.Moreover, the remission time and disappearance time of the clinical symptoms in observation group were significantly shorter than control group （P〈0.05）. No obvious adverse reactions occurred in both groups. Conclusion Modified Xuanyutongjing Decoction is an effective adjuvant treatment for patients with threatened abortion, which can ameliorate the serum E2, P, and β-hCG levels, alleviate the clinical symptoms, increase pregnancy survival rat and have no obvious adverse reactions, and is worthy of clinical application.
作者
滕丽丹
TENG Lidan(Shenyang Second Traditional Chinese Medicine Hospital,Shenyang 110100,Liaoning Province,China)
出处
《中国实用乡村医生杂志》
2018年第9期57-59,62,共4页
Chinese Practical Journal of Rural Doctor
关键词
宣郁通经汤
先兆流产
临床疗效
Xuanyutongjing Decoction
Threatened Abortion
Clinical Efficacy
