摘要
目的评价血管紧张肽转化酶抑制药(ACEI)对放射性肺损伤的保护作用,并通过网状Meta分析的方法将ACEI与血管紧张肽Ⅱ受体抑制药(ARB)、他汀类药物、类固醇类药物、非甾体抗炎药(NSAID)对放射性肺损伤的治疗效果进行简单评价。方法检索PubMed、EMbase、Cochrane Library,以及中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普(VIP)、万方数据库等,时间为建库至2017年3月1日,采用纽卡斯尔-渥太华量表(NOS)对纳入研究进行评分,采用Stata14.0版软件分析结果及排序。结果 ACEI在放射性肺炎的治疗中效果较理想,可有效降低放射性肺损伤的发生率,但不能延长患者生存时间;他汀类药物以及NSAID保护作用仅次于ACEI类药物。敏感性分析显示结果稳健,且ACEI类药物对放射性肺损伤的治疗效果不受患者性别及年龄的影响。结论 ACEI类药物对放射性肺损伤具有良好的保护作用。
Objective To evaluate the protective effect of ACEI drugs on radiation pneumonitis,and to compare ACEI with ARB,statin,steroid,and NSAID on the treatment of radiation induced lung injury through the network Meta-analysis.Methods A computer-based online search of PubMed,EMbase,Cochrane Library,as well as CNKI,CBM,VIP, Wanfang database was conduce.The NOS score was used to evaluate the quality of studies,and the results were analyzed by stata14.0 software.Results ACEI drugs showed desired effect on the treatment of radiation pneumonia,which can effectively reduce the incidence of radiation-induced lung injury,but can not prolong the survival time of the patients.The protective effects of statins and non-steroid anti-inflammatory drugs are second only to those of ACEI.Meta-analysis results were proved to be stable and credible by the sensitive-analysis.The therapeutic effect of ACEI on radiation induced lung injury is not affected by sex and age of patients.Conclusion ACEI drugs have an optimum protective effect on radiation induced lung injury.
作者
赵春阳
杨立超
蔡佳怡
姜明燕
ZHAO Chunyang;YANG Lichao;CAI Jiayi;JIANG Mingyan(Department of Pharmacy,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;School of Pharmacy, China Medical University,Shenyang 110001,China)
出处
《医药导报》
CAS
北大核心
2018年第11期1404-1408,共5页
Herald of Medicine
基金
辽宁省科技厅"产业共性技术创新平台"资助项目(2014226033)
