摘要
目的探讨临床反复输血患者红细胞不规则抗体的分布情况。方法对新乡地区2015年1月至2017年12月618例反复输血患者采用微柱凝胶法进行不规则抗体筛查,并对不规则抗体筛选阳性标本进行抗体鉴定及分类,结合患者的病史、输血史及妊娠史进行统计分析。结果 618例反复输血患者检出不规则抗体阳性32例,其中Rh血型系统抗体21例(65.63%),分别为抗-E 7例(21.88%),抗-Ec 9例(28.13%),抗-D 3例(9.38%),抗-Ce 1例(2.11%),抗-DC 1例(3.12%);MN血型系统2例(6.25%);冷抗体2例(6.25%);Kidd系统1例(3.12%);Lewis系统1例(3.12%);自身抗体2例(6.25%);3例患者未确定抗体特异性。男、女性患者不规则抗体阳性率分别为4.56%(12/363)和7.84%(20/255),女性患者不规则抗体阳性率高于男性(χ~2=5.620,P<0.05)。男性输血史≥3次和<3次患者不规则抗体阳性率分别为3.89%(11/283)、1.25%(1/80),男性输血史≥3次患者不规则抗体阳性率高于输血史<3次患者(χ~2=1.288,P<0.05)。女性妊娠史和输血史均≥3次患者和输血史<3次患者女性不规则抗体阳性率分别为9.13%(20/219)、0.00%(0/36),妊娠史和输血史均≥3次患者不规则抗体阳性率高于输血史<3次患者(χ~2=3.249,P<0.05)。结论反复输血患者更易产生不规则抗体,主要为Rh血型系统抗体,且女性产生不规则抗体的概率高于男性。
Objective To observe the distribution of irregular antibodies in patients undergoing repeated blood transfusion.Methods The irregular antibodies of 618 patients underwent repeated blood transfusion from January 2015 to December 2017 in Xinxiang area were screened by microcolumn gel method,and the antibodies were identified and classified according to the patients′ history,blood transfusion history and pregnancy history.Results Among the 618 patients,32 patients were positive of the irregular antibodies,of which 21 cases were Rh blood group system antibodies.Among the 21 patients,there was 7 cases of anti-E（21.88%）,9 cases of anti-Ec（28.13%）,3 cases of anti-D（9.38%）,1 case of anti-Ce（2.11%）,and 1 case of anti-DC（3.12%）.In addition,there was 2 cases（6.25%） of MN blood group antibodies,2 cases（6.25%） of cold antibodies,1 case（3.12%） of Kidd antibodies,1 case（3.12%） of Lewis antibodies and 2 cases（6.25%） of autoantibodies;the specificity of antibody was not determined in 3 patients.The positive rate of irregular antibody in male and female patients was 4.56%（12/363） and 7.84%（20/255）,respectively;the positive rate of irregular antibody in female patients was significantly higher than that in male patients（ χ^2=5.62, P 〈0.05）.The positive rate of irregular antibody in male patients with more than three times of transfusion history and less than three times of transfusion history was 3.89%（11/283）,1.25%（1/80） respectively;the positive rate of irregular antibody in patients with more than three times of transfusion history was significantly higher than that of patients with less than three times of transfusion history（ χ^2=1.288, P 〈 0.05）.The positive rate of irregular antibody in female patients with both pregnancy history and transfusion history more than three times and transfusion history less than three times was 9.13%（20/219）,0.00%（0/36） respectively;the positive rate of irregular antibody in patients with both pregnancy history and transfusion history more than three times was significantly higher than that in patients with transfusion history less than three times（ χ^2=3.249, P 〈0.05）.Conclusion Patients undergoing repeated transfusion are more likely to produce irregular antibody,the mainly irregular antibody was Rh blood group system antibody,and women are more likely to produce irregular antibodies than men.
作者
庞桂芝
张趁利
娄白敏
赵凤莲
鲍瑞玲
PANG Gui-zhi;ZHANG Chen-li;LOU Bai-min;ZHAO Feng-lian;BAO Rui-ling(Xinxiang Central Blood Stations,Xinxiang 453000,Henan Province,China;Department Transfusion,the First People′s Hospital of Xinxiang,Xinxiang 453000,Henan Province,China;Department Transfusion,Xinxiang Central Hospital,Xinxiang 453000,Henan Province,China)
出处
《新乡医学院学报》
CAS
2018年第10期899-901,共3页
Journal of Xinxiang Medical University
基金
新乡市科学发展计划基金资助项目(编号:05S003)
关键词
反复输血
妊娠
不规则抗体筛查
输血安全
repeated blood transfusion；pregnancy；irregular antibody screening；safety of blood transfusion
