摘要
An iodine-PPh3 mediated sulfenylation of indoles in water with stable and odorless sodium sulfinates as the sulfur source is described. The reaction could afford monosulfenylated indoles in moderate to excellent yields under metal free conditions. Moreover, double C--H sulfenylation of in- doles at 2- and 3-positions has also been achieved by using excess sodium sulfinates under the optimized reaction conditions.
An iodine-PPh3 mediated sulfenylation of indoles in water with stable and odorless sodium sulfinates as the sulfur source is described. The reaction could afford monosulfenylated indoles in moderate to excellent yields under metal free conditions. Moreover, double C--H sulfenylation of in- doles at 2- and 3-positions has also been achieved by using excess sodium sulfinates under the optimized reaction conditions.
