摘要
Aromatic compounds often serve as widely available and fundamental synthetic materials in polymers,paints,cosmetics,and pharmaceuticals.The development of novel transformations based on simple aromatics to access highly value-added structures is in great demand.In this regard,catalytic asymmetric dearomatization(CADA)reactions can convert planar aromatic compounds
Aromatic compounds often serve as widely available and fundamental synthetic materials in polymers, paints, cosmetics, and pharmaceuticals. The development of novel transformations based on simple aromatics to access highly value-added structures is in great demand. In this regard, catalytic asymmetric dearomatization （CADA） reactions can convert planar aromatic compounds into enantio-enriched three-dimensional cyclic molecules （Scheme 1）. The past several years have witnessed significant progress in CADA reactions and a large number of strategies have been developed. These reported methods include oxidative dearomatization reactions, dearomatization by hydrogenation, dearomatization by Diels-Alder and related reactions, allylic arylative, and Beck-type dearomatization, Reissert-type dearomatization, etc. Among these methods, dearomatizaton is generally initiated by thermal-activated processes.
基金
supported by the National Key R&D Program of China(2016YFA0202900)
the National Basic Research Program of China(2015CB856600)
the National Natural Science Foundation of China(21332009)
Program of Shanghai Subject Chief Scientist(16XD1404300)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000)
Key Research Program of Frontier Sciences of the Chinese Academy of Sciences(QYZDYSSWSLH012)
