摘要
目的:观察肺胀Ⅰ号方治疗AECOPD痰热壅肺型患者的临床疗效。方法:将60例AECOPD痰热壅肺型患者,随机分为对照组和治疗组各30例,对照组患者给予常规西医治疗,治疗组患者在对照组患者常规西医治疗基础上加服肺胀Ⅰ号方,比较两组患者的临床疗效、治疗前后中医证候积分及血常规、C反应蛋白(CRP)的变化。结果:治疗组患者临床疗效优于对照组(P<0.05)。两组患者治疗后5天、10天与治疗前证候积分比较,均有下降(P均<0.01),但治疗组下降更明显(P<0.05)。治疗组患者在改善主症、次症方面均优于对照组(P均<0.05)。两组患者治疗10天后WBC、NE%、CRP较治疗前均明显下降(P<0.05),但差异无统计学意义(P>0.05)。两组患者治疗期间均未发生严重不良反应。结论:肺胀Ⅰ号可提高AECOPD痰热壅肺型患者的临床疗效,能较快改善患者临床症状,且无明显不良反应,值得临床推广应用。
Objective：To observe the clinical efficacy of Feizhang Ⅰ decoction for patients with Acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods：60 patients with AECOPD who met the traditional Chinese medicine syndrome differentiation criteria of phlegm-heat obstructing lung sydrome were enrolled.The patients were randomLy divided into two groups（therapeutic group 30 cases and control group30 cases,respectively）.The therapeutic group was treated by Feizhang Ⅰ decoction combined with conventional therapy while the control group was treated with conventional therapy only.Two groups were treated for 10 days.The clinical efficacy,the changes of TCM syndrome scores and laboratory indexes of routine blood test,C reactive protein before and after treatment were compared before and after treatment.Results：The Clinical efficacy of the treatment group is better than that of the control group（the obvious effective rate were 66.7%vs33.3%,the total effective rate were 93.4%vs90%,P〈0.05）.Comparising with baseline,the TCM syndrome scores of 5 days and 10 days after the treatment in the two groups were decreased（P〈0.01,respectively）,but the therapeutic group decreased significantly compare with control group after treatment.（P〈0.05）.The therapeutic group were better than the control group in the improvement of major symptoms and secondary symptoms（P〈0.05）.WBC,NE%,CRP in two groups decreased significantly after 10 days treatment（P〈0.05,respectively）,but the difference didn＇t reach statistically significance.There were no serious adverse reactions during the treatment in the two groups.Conclusion：Feizhang Ⅰ decoction could promote the clinical effects of AECOPD patients with phlegm-heat obstructing lung syndrome.It olsa,could quickly improve patients＇ clinical symptoms.There were no obvious adverse reactions.It is worth popularizing in clinical practice.
作者
高如花
黄小华
洪春霖
黄锦榕
洪敏俐
Gao Ruhua;Huang Xiaohua;Hong Chunlin;Huang Jinrong;Hong Minli(Zhangzhou Affiliated TCM Hospital of Fujian University of Traditional Chinese Medicine.Zhangzhou 363000,China;Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China)
出处
《亚太传统医药》
2018年第9期176-179,共4页
Asia-Pacific Traditional Medicine
基金
福建省中医肺系病重点研究室建设项目(内科类-5)
漳州市自然科学基金项目(ZZ2014J25)
漳州市中医专科专病人才培训基地建设项目((2016)100)
关键词
慢性阻塞性肺疾病
急性加重期
肺胀Ⅰ号方
临床研究
Chronic Obstructive Pulmonary Disease
Acute Exacerbation
FeizhangI Decoction
Clinical Research
