摘要
目的:探讨慢性阻塞性肺疾病急性加重患者营养状况及免疫功能情况,并分析营养支持在慢性阻塞性肺疾病急性加重期(AECOPD)对临床疗效、免疫指标、肺功能及营养状况的影响。方法:选取180例非急性加重的患者作为对照组,再选取360例慢性阻塞性肺疾病急性加重的患者,按就诊先后顺序分为观察组Ⅰ和观察组Ⅱ,每组180例,分析3组患者治疗干预前的营养状况及免疫功能特点。观察组Ⅰ患者给予慢阻肺急性加重的常规治疗方案,观察组Ⅱ患者在常规治疗基础上采用早期营养支持,观察治疗1个月后两组患者的临床疗效、营养状况、免疫指标、肺功能的改善情况,并采用CAT评分法评价慢阻肺症状改善情况。结果:治疗干预前,对照组患者的免疫功能明显优于观察组(P<0.05),观察组Ⅱ患者的临床疗效优于观察组Ⅰ(P<0.05),差异具有统计学意义;治疗后,观察组Ⅱ患者的肺活量、第1秒用力肺活量、第1秒率、Fe NO、Th1/Th2、CAT的改善程度均优于观察组Ⅰ,差异具有统计学意义(P<0.05),观察组Ⅱ患者的营养状况得到明显改善,差异具有统计学意义。结论:早期营养支持有利于慢阻肺急性发作患者的康复,是改善预后的重要治疗手段。
[Objective] To investigate the nutritional staus and immune function of patients with acute exacerbation of chronic obstructive pulmonary disease, and the effects of nutritional support in the acute exacerbation of chronic obstructive pulmonary disease （AECOPD） on clin-ical efficacy, immune parameters, pulmonary function and nutritional status. [Method] Totally 180 patients with non-acute exacerbation were se-lected as control group, patients with AECOPD were selected and divided into observation groupI and observation group Ⅱ according to the order of treatment The observation group I received routine treatment, the observation group Ⅱ was given early nutrition support. The clinical efficacy, nutritional status, immune indicators, and lung function of the two groups of patients were observed after one month of treatment, the CAT method was used to evaluate the improvement of COPD symptoms. [Result] Before treatment intervention, the immune function of the control group was significantly better than that of the observation group （P 〈0. 05） . The clinical efficacy of the observation group Ⅱ was better titan that of the observation group I （P 〈0. 05） . After treatment, the vital capacity, the first second of forced vital capacity, the first second rate, Fe-NO, Thl/Th2, the improving degree of CAT of the observation group Ⅱ were better titan that of the observation group I, the diffence was sta-tistically significant （P 〈0. 05） . The nutritional status of the observation groupⅡ was significantly improved. [Conclusion] Early nutrition support is beneficial to the recovery of patients with AECOPD, which is an important treatment for improving prognosis.
作者
杜娟
邱丽
张盼
易静叶
任徽
DU Juan;QIU Li;ZHANG Pan;YI Jing-ye;REN Hui(Respiratory and Critical Diseases Medicine,The First Affiliated Hospital of Xi＇an Jiaotong University,Xi ＂an 710061,China)
出处
《中国食物与营养》
2018年第8期76-79,共4页
Food and Nutrition in China
基金
陕西省国际科技合作与交流计划(项目编号:2016KW-028)
关键词
营养状况
慢性阻塞性肺疾病
免疫功能
nutritional status
chronic obstructive pulmonary disease （COPD）
immune function
