摘要
目的 探讨钙粘附分子E cadherin(E CD)和CD44v6的表达与膀胱移行细胞癌发生及发展的关系。 方法 应用S P免疫组化染色法检测 96例膀胱移行细胞癌中E CD和CD44v6的表达。 结果 E CD和CD44v6阳性率分别为 :Ⅰ级 86 .7% (2 6 / 30 ) ,80 .0 % (2 4/ 30 ) ;Ⅱ级 5 2 .8% (19/ 36 ) ,6 9.4% (2 5 / 36 ) ;Ⅲ级 2 6 .7% (8/ 30 ) ,33 .3 % (10 / 30 )。E CD和CD44v6阳性率与膀胱移行细胞癌分级、分期 ,复发及生存率显著相关 (P <0 .0 1)。 结论 E CD和CD44v6阳性表达率与膀胱移行细胞癌生物学特性密切相关。
Objective To study the expressions and clinical significance of E cadherin(E CD) and CD44v6 in bladder transitional cell cancinoma. Methods The expressions of E CD and CD44v6 of 96 cases of bladder transitional cell cancer were detected by streptavidin peroxidase immunohistochemical method. Results The positive expression rates of E CD and CD44v6 were as follows:Grade Ⅰ,86.7%(26/30),80.0%(24/30);Grade Ⅱ,52.8%(19/36),69.4%(25/36);Grade Ⅲ,26.7%(8/30),33.3%(10/30), P <0.01,respectively.Significant relation of positive expressions of E CD and CD44v6 with the degree,stage of tumor and the high rate of reccurrence and survival were observed. Conclusions The positive expressions of E CD and CD44v6 are significantly related to the biological behavior of bladder transitional cell cancinoma.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2002年第8期494-497,共4页
Chinese Journal of Urology
