摘要
目的:优化五黄液中冰片的最佳溶解工艺。方法:采用GC法,以萘为内标,冰片含量为评价指标,采用-响应面优化法(Central Composite Design-Response Surface Method CCD-RSM)优化五黄液中冰片最佳溶解工艺参数。结果:最佳溶解工艺参数为乙醇∶吐温∶冰片=9∶3∶1,冰片的平均含量为68.2%。结论:CCD-RSM设计科学、预测性好,所得的冰片溶解工艺简便稳定,合理可行。
Objective： To optimize the preparation of borneol in Wuhuangye. Methods： Using Gas chromatography, taking the contents of naphthalene as internal standard and the contents of borneol as indexes, optimizing the preparation of borneol in Wuhuangye by using Central Composite Design-Response Surface Method （CCD-RSM） . Results： The best preparation technology were as follows： alcohol： twain： borneol =9： 3： 1, the contents of borneol was 68. 2%. Conclusion： CCD-RSM is scientific and predictability, this technology is simple, stable, reasonable and feasible.
作者
廖芳
田吉
陈斯玮
谭天林
王欢
马书军
张丹
Liao Fang;Tian Ji;Chen Siwei;Tan Tianlin;Wang Huan;Ma Shujun;Zhang Dan(Traditional Chinese Medicine Hospital of Xindu district, Chengdu, 610500, China;Research Center for Drug Discovery, Southwest Medical University, Luzhou, 646000, China;Pharmacy Department, Southwest Medical University, Luzhou, 646000, China)
出处
《成都中医药大学学报》
2018年第2期15-17,126,共4页
Journal of Chengdu University of Traditional Chinese Medicine
基金
全国中药特色技术传承人才培训项目(J20164811007)
成都市新都区科技局项目
