摘要
目的分析恶性孤立性肺结节的危险因素。方法选择于郑州大学人民医院2015年1月至2016年12月就诊的318例SPNs患者,病灶均经手术切除并且有明确病理诊断。通过MyrianTMXP-Lung Nodule医学影像分析系统对病灶进行三维重建及特征量化,分析年龄、性别、临床病史、结节大小及影像学表现等因素与孤立性肺结节良恶性的关系。结果 318例SPNs患者中,恶性214例(67.3%),良性104例(32.7%)。Logistic回归结果显示,瘤-肺界面光整、瘤-肺界面清楚、空泡征、毛刺、分叶及COPD病史与SPNs的良恶性相关(P<0.05)。结论 COPD病史、结节钙化、瘤-肺界面光整、瘤-肺界面清楚、空泡征、分叶及毛刺有助于SPNs良恶性的判断。
Objective To analyze the independent risk factors of malignant lesions in solitary pulmonary nodules（ SPNs）.Methods Three hundred and eighteen cases with SPNs were selected in the People＇s Hospital of Zhengzhou University from January of 2015 to December of 2016. All the lesions of these patients were surgically removed and had definite pathological diagnosis. The clinical and radiological data were reviewed. Three-dimensional reconstruction and feature quantification of lesions were performed by MyrianTMXP-Lung Nodule medical image analysis system. Single factor binary regression was performed in the univariate analysis and logistic regression in multivariate analysis of age,gender,clinical history,size and radiological characteristics of the nodule. Results There were 214 cases（ 67. 35%） with malignant SPNs and 104 cases（ 32. 7%） with benign SPNs.Based on the Logistic regression analysis,the smoothness and clearity of tumor-lung interface,the sign of vacuole,burr and lobulation,and COPD medical history were significantly correlated with the differential diagnosis of benign and malignant SPNs（ P〈0. 05）. Conclusion The medical history of COPD,tuberculous calcification,tumor-lung interface smoothing,tumor-lung interface clear,vacuolate sign,lobulation and burr will facilitate the differential diagnosis of benign and malignant SPNs.
作者
刘海洋
程相松
安云霞
马利军
Liu Haiyang;Cheng Xiangsong;An Yunxia;Ma Lijun(The People＇sHospital of Zhengzhou University,Zhengzhou 450003,Chin)
出处
《河南医学研究》
CAS
2018年第7期1173-1176,共4页
Henan Medical Research
关键词
孤立性肺结节
肺癌
危险因素
三维重建
solitary pulmonary nodules
lung cancer
risk factors
three-dimensional reconstruction
