摘要
目的：研究COPD与肺癌发病的相关性。方法收集2010年11月至2013年11月我院收治的门诊或住院患者210例肺癌患者作为实验组,同时选取在玉林市红十字会医院体检中心体检的非癌健康人226例作为对照组,观察2组研究对象个人呼吸系统疾病史、家族呼吸系统疾病史与肺癌之间的关系,同时观察2组中吸烟患者和不吸烟患者的 COPD 发生率。结果呼吸系统疾病中肺炎、哮喘与肺癌的发生无显著关系（P 值均〉0.05）；伴有 COPD、支气管炎、肺气肿、肺结核的患者,发生肺癌的风险显著增高（P 值均〈0.05）,其中 COPD 与肺癌发生的关联性最强（OR =2.73）。具有COPD及肺癌家族史的人群,发生肺癌的风险显著增加（P〈0.05）。吸烟患者中实验组COPD的发生率显著高于对照组（χ^2=5.482,P〈0.05）；实验组未吸烟患者中实验组 COPD的发生率显著高于对照组（χ^2=5.901,P〈0.05）。结论患有COPD病史及有 COPD家族史的患者,发生肺癌的风险增加,且COPD患者无论是否吸烟,COPD仍然会导致肺癌发生的风险性增加。
Objective To study the correlation between chronic obstructive pulmonary disease （COPD） and lung cancer.Methods Two huandred and ten lung cancer patients collected in our hospital from November 2010 to November 2013 were regarded as experimental group,and 226 healthy people without any cancer collected in the center of healthy physical of our hospita at the same time were regarded as control group,to observe the relationship between the two factors （such as the history of personal respiratory disease,family history of respiratory disease） and lung cancer,then to compare the rate of COPD between smoking patients and not smoking patients in two groups.Results Among the respiratory system diseases,pneumonia and asthma were no significant related lung cancer（all P〉0.05）;the patients sufferring from COPD,bronchitis,emphysema,pulmonarytuberculosis,increasedsignificantly the risk of lung cancer （all P 〈0.05）,the relationship between COPD and lung cancer was highest （OR =2.73）.People with family history of COPD and lung cancer,had a significant increase in the risk of lung cancer（P〈0.05）.The rate of COPD among smoking patients of experimental group was significantly higher than the control group（χ^2=5.482,P〈0.05）.The rate of COPD among not-smoking patients of experimental group was significantly higher than control group （χ^2=5.901,P 〈0.05）.Conclusions Patients with COPD or a family history with COPD,will increase the risk of lung cancer,and whether or not to smoke,COPD will still increase the risk of lung cancer.
出处
《国际呼吸杂志》
2016年第23期1786-1789,共4页
International Journal of Respiration
关键词
慢性阻塞性肺疾病
肺癌
Chronic obstructive pulmonary disease
Lung cancer
