摘要
目的分析舒利迭对老年慢性阻塞性肺疾病(COPD)急性加重期患者的疗效及对凝血功能的影响。方法选取来我院就诊的处于COPD急性加重期的老年患者,共116例,按就诊编号奇数、偶数分成2组。两组基础治疗一致,对照组只给予基础治疗,观察组另外加用舒利迭治疗。分析舒利迭对COPD急性加重期患者的治疗效果,及其对肺功能、血气指标及凝血指标的影响。结果治疗后,观察组总有效率(94.83%)明显高于对照组(79.31%)(P<0.05),两组肺功能FEV1%预计值、FEV1/FVC、MMEF值均升高,血气指标Pa O2、血p H值均升高,Pa CO2均下降,两组凝血指标PT、APTT均延长,FBG、D-D均下降,且观察组改善程度明显优于对照组(P<0.05)。治疗期间,通过患者主诉和观察,均未发现明显不良反应。结论基础治疗联合舒利迭可更有效地控制老年COPD急性加重期患者的症状、改善凝血功能,且用药安全。
Objective To analyze the curative effect of seretide on elderly chronic obstructive pulmonary disease（ COPD） patients of acute exacerbation and its influence on coagulation function. Methods Totally 116 elderly patients with acute exacerbation of elderly COPD were divided into 2 groups according to the number of odd numbers and even numbers. The basic treatments of 2 groups were consistent. Control group was given basic treatment,and observation group was additionally given seretide treatment. The effect of seretide on curative effect,pulmonary function,blood gas index and coagulation index in patients with acute exacerbation of COPD were analyzed. Results After treatment,the total effective rate of observation group（ 94. 83%） was higher than that of control group（ 79. 31%）（ P〈0. 05）. The prediction value of FEV1%,FEV1/FVC and MMEF in lung function of two groups were improved. The Pa O2 and blood p H value were improved,while Pa CO2 were decreased in the two groups. The PT and APTT were prolonged,both FBG and D-D were decreased,and the improvement of observation group was superior to that of control group（ P〈0. 05）. During the treatment,no obvious adverse reaction was found through the patient＇s complaint and observation. Conclusion Basic therapy combined with seretide can effectively and safely control the symptoms and improve the coagulation function of elderly patients with acute exacerbation of COPD.
作者
刘丽娟
张齐武
刘宇鹏
胡瑛
周尧
LIU Li-juan;ZHANG Qi-wu;LIU Yu-peng;HU Ying;ZHOU Yao(Respiratory Department, Chinese People＇s Liberation Army 210th Hospital, Dalian 116021, China)
出处
《实用药物与临床》
CAS
2018年第5期541-544,共4页
Practical Pharmacy and Clinical Remedies
关键词
慢性阻塞性肺疾病
急性加重期
老年患者
凝血功能
舒利迭
Chronic obstructive pulmonary disease
Acute exacerbation
Elderly patients
Coagulation function
Seretide
