摘要
外泌体是一种区别于微泡具有特异脂质、蛋白、mRNA和miRNA的小的膜性囊泡结构。虽然外泌体提取方法很多,但纯度大都不理想。外泌体主要具有细胞间信号传导、提呈抗原以及诱发和增强机体免疫反应、参与血管新生等功能。文章简要介绍了外泌体及其在心脑血管、肝脏、肾脏等系统炎症性疾病发生、发展及损伤修复等方面的相关作用,并对其在口腔领域的研究做出一定的前景展望。
Exosomes, known as the outer row of body, is a kind of small membranous vesicle structure with specific lipids, mRNA, miRNA and proteins, different from the microbub- bles. Although there are a lot of exsomes extraction methods, the purity is still not ideal. Exosomes can mediate intercellular signaling, present the antigens, induce and enhance im- mune response, promote angiogenesis and so on. This paper has briefly introduced exosomes and its role in the occurrence, development and injury repair of cardiovascular and cerebro- vascular, liver, kidney and other inflammatory diseases.We al- so make some prospects on its research in dental field.
作者
刘娜娜
郑妍
林莉
LIU Na-na;ZHENG Yan;LIN Li.(Department ofPeriodontology, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China)
出处
《中国实用口腔科杂志》
CAS
2018年第3期129-133,共5页
Chinese Journal of Practical Stomatology
基金
国家自然科学基金(81470744)
关键词
外泌体
组成
提取
检测
免疫
慢性炎症
exosome
composition
extraction
detection
immune
chronic inflammation
