摘要
[目的]探索节拍化疗联合放疗对局部晚期非小细胞肺癌的近期疗效、抑制肿瘤血管新生作用,并评价其毒副作用。[方法]2015年8月至2016年8月住院治疗的57例非小细胞肺癌患者,随机分为治疗组和对照组。治疗组以紫杉醇8mg/m2＋卡铂AUC=0.25mg/ml.min（每周二次）的节拍化疗联合放疗;对照组以紫杉醇45-50mg/m^2＋卡铂AUC=2mg/ml.min（每周一次）与放疗行同步放化疗。治疗前后行CT扫描及血流灌注分析,并评价其毒副作用。[结果 ]对照组与治疗组比较总有效率略有优势,但无统计学差异（P〉0.05）。两组之间Ⅲ~Ⅳ度不良反应发生率有显著性差异（P〈0.05）;两组患者经治疗后血流灌注得到改善,节拍化放疗组稍显著,其中治疗后BV、PS改善差异达统计学意义。[结论]节拍化疗联合放疗毒副作用小,耐受性好,并且具有更好的抗肿瘤血管效应。
[Objective]To evaluate the short-term efficacy and adverse reactions of metronomic chemotherapy combined with radiotherapy in locoregionally advanced non-small-cell lung cancer（NSCLC）.[Methods]Fifty seven patients with locoreginally advanced NSCLC admitted from August 2015 to August 2016 were randomized into two groups：29 cases received metronomic chemotherapy with radiotherapy（paclitaxel 8 mg/m2 and carboplatin AUC=0.25 mg/ml.min,twice a week,study group）and 28 cases received concurrent chemotherapy with radiotherapy（paclitaxel45 ~50 mg/m2 and carboplatin AUC =2 mg/ml.min,once a week,control group）.CT scan and blood perfusion analysis were performed before and after treatment;the adverse effects were also evaluated in two groups.[Results]There was no significant difference in overall effective rate between study group and control group.The incidence of Ⅲ~Ⅳ adverse effects in study group was significantly lower than that in control group.The blood flow was improved after treatment in both groups,but that in study group was improved more markedly,the differences in blood volume（BV）and permeability surface（PS）were significant between two groups.[Conclusion ]Metronomic chemotherapy combined with radiotherapy has lower adverse effect incidence,better tolerance and better anti-angiogenesis effect.
作者
孙莉
郭颖
陈卫东
SUN Li;GUO Ying;CHEN Wei-dong(Shengli Hospital of Shengli Petroleum A dministration ,Dongying 257055, Chin)
出处
《肿瘤学杂志》
CAS
2018年第3期218-220,共3页
Journal of Chinese Oncology
关键词
非小细胞肺癌
节拍化疗
放疗
肿瘤血管新生
non-small-cell lung cancer
metronomic chemotherapy
radiotherapy
tumor angio-genesis
