摘要
通过数据挖掘,揭示组分与组分、组分与证型的关系,从组分层面解析中药治疗心血管疾病的配伍规律,为中医临床基于病证结合采用组分中药治疗疾病提供依据。通过对近20年期刊文献数据中关键点的采集及结构化加工,采用关联规则挖掘算法,对治疗心血管疾病的中药(中药材/饮片)、中成药及相关组分的研究结果进行挖掘分析。结果筛选出与临床治疗心血管疾病关联度较高的组分配伍,发现了新的配伍形式,印证或推测出构成单味中药和中药复方的药效物质基础和/或可能的组分配伍,揭示组分配伍与疾病、中医证型之间的关联关系。基于关联规则挖掘,可为组分配伍与优化提供新的思路和方法,为组分中药研发提供技术支撑。
To reveal the relationship between components and components, components and syndromes based on data mining. Analyzing the component compatibility regularity in treatment of cardiovascular diseases from the component level provides the basis for treating the diseases with multi-component Chinese medicine based on the combination of syndrome and symptom in Chinese medicine clinic. Through the collection and structural processing of the key points in the literature data in recent 20 years, the mining results of Chinese material medica（Chinese medicinal materials/decoction pieces）, Chinese patent medicine and related components for the treatmet of cardiovascular diseases were analyzed by association rules mining algorithm. The component compatibilities for treating cardiovascular diseases with a higher correlation were screened out. New component compatibility forms were found. The effective substances and/or possible component compatibility of single herb and Chinese herbal compound were confirmed or speculated. The relationship between components compatibility and diseases, components and syndromes were revealed. Based on association rules mining, it can provide new ideas and methods for component compatibility and optimization, and provide technical support for the research and development of component Chinese medicine.
作者
苗青
胡镜清
张俊华
岳广欣
柏冬
刘振丽
王淳
王瑞海
宋志前
杨阳
刘丽梅
MIAO Qing1, HU Jing-qing1, ZHANG Jun-hua2, YUE Guang-xin1, BAI Dong1, LIU Zhen-li1, WANG Chun1, WANG Rui-hai1, SONG Zhi-qian1, YANG Yang3, LIU Li-mei1(1. Institute of Basic Theory for Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China 2. Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 3. Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, Chin)
出处
《中草药》
CAS
CSCD
北大核心
2018年第6期1461-1467,共7页
Chinese Traditional and Herbal Drugs
基金
国家重点基础研究计划("973")项目(2012CB518401)
关键词
组分配伍
心血管疾病
关联规则
组分-组分关系
组分-证型关系
component compatibility
cardiovascular diseases
association rule
component-component relationship
component-syndrome relationship
