摘要
"中药组分"概念的提出,在一定程度上把中药多成分、多靶点的复杂性问题简单化,对于中药药效物质基础的阐明提供了可能;也为推进中医药现代化、产业化,推动中医药事业、产业高质量发展提供了新方向。方药-病证相关性研究进展迅速,无论基础研究,还是临床应用都是硕果累累。然而,组分-病证相关性研究尚需深入。血瘀证是中医学临床常见的证型,涉及多种疾病,尤其在心脑血管疾病、肾病、糖尿病、高脂血症中更为常见。大量研究结果表明一些中药及中药复方的特定组分能够改善血瘀证患者或实验动物模型的相关指标,具体表现在降低血液黏度、抑制血小板活化和黏附聚集、改变红细胞变形指数、抑制血栓形成等。血瘀既是多种疾病的致病因素,亦是多种疾病的病理产物,涉及范围甚广。因此,本研究将对中药不同组分在血瘀证防治方面的进展进行研究,围绕皂苷类组分、黄酮类组分、有机酸类组分、多糖类组分、生物碱类组分及其他活性成分在改善血液流变学异常、高凝状态、血小板活化和黏附聚集、血栓形成方面进行综述。基于组分-病证相关的思想,检索近20年的相关文献,分类总结不同组分在血瘀证防治的成果,希望能为中药组分药理作用研究、中药组分配伍研究、中药组分制剂研究等方向的深入研究提供些许思路。
To a certain extent,put forward the concept of"component of traditional Chinese medicine(TCM)"simplifies the complexity of multi-component and multi-target of TCM,which provides a possibility for the clarification of the material basis of the efficacy of TCM,and also provides a new direction for promoting the modernization and industrialization of TCM,promots the high quality development of TCM.The correlation between prescription and disease syndrome has made rapid progress,both basic research and clinical application are fruitful.However,the correlation between components and disease syndrome still needs to be further studied.The syndrome of blood stasis is a common syndrome of TCM science,and it is more common in various diseases,especially cardiovascular and cerebrovascular diseases,kidney disease,diabetes and hyperlipoidemia.A large number of studies have shown that some specific components contained in TCM or TCM compound can improve the related indexes of patients or experimental animal model with blood stasis syndrome.It is manifested in reducing blood viscosity,inhibiting platelet activation and adhesion aggregation,changing erythrocyte deformability index,inhibiting thrombosis and so on.Blood stasis is not only the pathogenic factor of many diseases,but also the pathological product of many kinds of diseases,which involves a wide range of diseases.Therefore,this study will study the progress of different components of TCM in the prevention and treatment of blood stasis syndrome,focusing on saponins,flavonoids,organic acids,polysaccharides,alkaloids and other active components in improving hemorheological abnormalities,hypercoagulability,platelet activation and adhesion aggregation,thrombosis.Based on the thought of component-disease syndrome,this paper searches the relevant literature in recent 20 years,classifies and summarizes the achievements of different components in the prevention and treatment of blood stasis syndrome,and hopes to provide some ideas for the further study of the pharmacological action of TCM components,the study of compatibility of TCM components and the research of TCM components.
作者
张玉昆
冯月男
孙思邈
肖洪彬
牛雯颖
ZHANG Yu-kun;FENG Yue-nan;SUN Si-miao;XIAO Hong-bin;NIU Wen-ying(Heilongjiang University of Chinese Medicine,Heilongjiang,Harbin 150040,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第10期220-226,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
黑龙江中医药大学科研基金项目(201739)
国家自然科学基金项目(81703981)
黑龙江省高校基本科研业务费支持计划项目(2017PT07)。
关键词
血瘀证
中药组分
研究进展
活血化瘀
皂苷
黄酮
有机酸
多糖
blood stasis syndrome
components of traditional Chinese medicine
research progress
promoting blood circulation and removing blood stasis
Saponins
flavonoids
organic acids
polysaccharides
