摘要
本实验选用一阶导数紫外分光光度法对氟脲嘧啶的血药浓度进行了测定,回收率为100.65%±1.77,CV 1.76%。揭示家兔体内氟脲嘧啶的药物动力学符合一室模型配置。其参数k=1.82±0.32h^(-1),t_(1/2)=0.39±0.07h,Vd=1.56±0.20L/kg。
This experiment is for the research on the pharmacokiretics of 5-Fu by deri-vative spectrophotmetry. When serum concentration of 5-Fu is tested by the mot-hod. The average recovery percent is 100. 56%±1.77 and CV is 1.76%. The pharma-cokinetics parameters have been determined by this method. And as a result,internal remedy is in conformity with the one-compartment, with parameterk=1. 82±0. 32h^(-1), T 1/2=0. 39±0. 07h Vd=1. 56±0. 20L/kg.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第8期339-341,共3页
Chinese Journal of Hospital Pharmacy
关键词
氟脲嘧啶
分光光度法
血药浓度
Derivative Spectrophotometry
Fluorouracilum
serum concentration
