摘要
本文应用高效液相色谱法测定血药浓度,对7例肿瘤患者静脉滴注5—氟尿嘧的药代动力学进行了研究。结果表明5—氟尿嘧啶在体内衰减呈一室开放模型,T2/1为14.82min,(?)为13(?)28L/kg,(?)为0.0728L/min.kg,AUC为121.25mg.min/L。本文还研究了12例肿瘤患者直肠给药后5—氟尿嘧啶在不同部位血清中分布情况,结果见表3。全部19例患者的血清中均测不到5—氟尿嘧啶的活性代谢物5—氟脱氧尿苷。
The pharmacokinetics of 5- fluorouracil (5-FU) was studied in 7 patients with neoplastic disease who received iv infusion of 5-FU. 5-FU concentrations were measured in serum by high performance liquid chromatography (HPLC). Serum concentrations of 5 -FU .were fitted a one-compartment open model adequately, The pharmacokinetic parameters were found to be: T1/2, 14.82 min; V, 1.3528 L/kg; Cl, 0.0728 L/min.kg; and AUC, 121.25 mg. min/L. We have attempted to measure mesenteric and systemic drug concentrations in 12 patients following rectal administration of 5-FU, and the results were listed in table 3. Metabolite 5- fluoro - 2' - deoxyuridine (FUdR) was not detected in all 19 patients who received 5-FU.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第2期91-93,共3页
Chinese Journal of Cancer
基金
国家自然科学基金(85-248)
