摘要
目的本研究探讨血清甲状腺激素水平与冠状动脉侧支循环(CCC)形成的关系。方法回顾性分析了2015年6月至2017年6月期间来我院检查且接受冠状动脉造影手术的429例患者。CCC程度按Cohen-Rentrop方法分类,通过化学发光免疫测定技术评估血清中三碘甲状腺原氨酸(FT3),游离甲状腺素(FT4)和促甲状腺激素(TSH)水平。结果糖尿病(P=0.019),吸烟(P<0.001),TSH(P<0.001),FT3(P<0.001),FT4(P=0.015)和SCH(P=0.015)在CCC形成良好与不良组中差异有统计学意义。在回归分析中,TSH(OR=2.397;95%CI=1.937-3.625;P<0.001),FT3(OR=0.169;95%CI=0.046-0.429;P<0.001),心力衰竭(OR=0.139;95%CI=0.039-0.754;P=0.027),并且高血脂症(OR=1.807;95%CI=1.010-3.234;P=0.042)是稳定冠状动脉疾病(CAD)患者CCC形成不良的独立预测因子。结论除传统危险因素外,SCH,高血清TSH浓度,低FT3水平与阻塞性CAD患者CCC形成有关。
Objective This study analyses the relationship between serum thyroid hormone levels and Coronary collateral circulation（CCC）formation.Methods A total of 429 patients who underwent coronary angiography from June2015 to June 2017 were retrospectively reviewed.Triiodothyronine（FT3）,free thyroxine（FT4）and thyroid stimulating hormone（TSH）were assessed by chemiluminescence immunoassay.The CCC degree is classified by the CohenRentrop method.Results The difference of the proportions of diabetes mellitus（P=0.019）,smoking（P〈0.001）and the levels of TSH（P〈0.001）,FT3（P〈0.001）,FT4（P=0.015）and SCH（P=0.015）was significant in poor CCC and Good CCC groups.In the regression analysis,TSH（OR=2.397;95% CI=1.937-3.625;P〈0.001）,FT3（OR=0.169;95% CI=0.046-0.429;P〈0.001）,heart failure（OR=0.139;95% CI=0.039-0.754;P=0.027）and hyperlipidemia（OR=1.807;95% CI=1.010-3.234;P=0.042）were independent predictors of poor CCC formation in coronary artery disease（CAD）patients.Conclusion In addition to the traditional risk factors,SCH,high serum TSH concentration,low FT3 levels were associated with CCC formation in obstructive CAD patients.
作者
梁彦
张沛欣
LIANG Yan;ZHANG Pei-xin(Department of Endocrinology, Tongchuan People＇s Hospital, Tongchuan 727000, Chin)
出处
《中国实验诊断学》
2018年第3期385-389,共5页
Chinese Journal of Laboratory Diagnosis
