摘要
目的:分析行冠状动脉造影术(CAG)的甲状腺功能异常患者冠状动脉(冠脉)病变严重程度及1年预后。方法:回顾性分析行CAG的患者625例,按造影前甲状腺功能分为甲状腺功能正常组、低T3综合征组、甲状腺功能减退症(甲减)组和甲状腺功能亢进症(甲亢)组。运用Gensini评分评价冠脉病变严重程度,随访1年。结果:低T3综合征组及甲减组冠心病检出率均明显高于甲状腺功能正常组(P<0.01);术中甲亢组冠脉痉挛的发生率明显高于甲状腺功能正常组(P<0.01);低T3综合征组和甲减组冠脉病变程度比甲状腺功能正常组重(均P<0.01)。甲亢组比甲状腺功能正常组发生心绞痛发作住院事件的发生率高(P<0.01);低T3综合征组、甲减组及甲亢组复合心血管事件(心绞痛发作住院、非致命性心肌梗死和心力衰竭)的发生率比甲状腺功能正常组高(均P<0.01)。结论:低T3综合征和甲减患者冠心病检出率高,冠脉病变严重程度增加。甲状腺功能异常患者1年预后差。
Objective：To analyze the severity of coronary artery lesions and the one year prognosis in patients with abnormal thyroid function.Method：The 625patients undergoing coronary artery angiography（CAG）were retrospectively analyzed.The patients were divided into four groups by thyroid function prior to CAG：euthyroidism group,low T3syndrome group,hypothyroidism group,and hyperthyroidism group.We assessed coronary artery lesions by Gensini scores.These patients were followed up for one year.Result：The morbidity rate of CHD in low T3syndrome group and hypothyroidism group was significantly higher than that in euthyroidism group（P 0.01,P=0.007,respectively）;The incidence of coronary spasm during CAG was significantly higher in hyperthyroidism group compared with euthyroidism group（P〈0.01）;Coronary artery severe lesions in low T3syndrome group and hypothyroidism group was significantly higher than that in euthyroidism group（all P〈0.01）.Compared to euthyroidism group,the incidence of re-hospital admission due to recurrent ischemic angina significantly increased in hyperthyroidism group（P〈0.01）;The incidence of combined cardiovascular events（re-hospital admission due to recurrent ischemic angina,non-fatal MI,heart failure）was significantly higher in low T3syndrome group,hypothyroidism group and hyperthyroidism group compared with euthyroidism group（all P〈0.01）.Conclusion：The patients in low T3syndrome group and hypothyroidism group have a high prevalence rate of CHD and the severity of coronary artery lesions increase in both group.The prognosis of the patients with thyroid dysfunction is poor during one year following up.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2014年第5期420-424,共5页
Journal of Clinical Cardiology
