摘要
目的探讨大蒜素软胶囊联合碘甘油治疗复发性口腔溃疡的临床效果。方法选取2015年10月—2017年10月北京市顺义区医院收治的104例复发性口腔溃疡患者,随机分为对照组和治疗组,每组各52例。对照组患者外用1%碘甘油,3次/d。治疗组在对照组治疗基础上口服大蒜素软胶囊,1粒/次,3次/d。两组均连续治疗2周。观察两组的临床疗效,同时比较两组治疗前后视觉模拟(VAS)评分、溃疡面积、肿瘤坏死因子(TNF)-α、C反应蛋白(CRP)、白介素(IL)-8、唾液表皮生长因子(EGF)、CD^(4+)/CD^(8+)的变化情况。结果治疗后,对照组和治疗组患者的总有效率分别为80.8%、94.2%,两组比较差异有统计学意义(P<0.05)。治疗后,两组VAS评分、溃疡面积、TNF-α、CRP、IL-8、唾液EGF显著降低,外周血CD^(4+)/CD^(8+)均显著增加,同组治疗前后比较差异具有统计学意义(P<0.05)。治疗后,治疗组VAS评分、溃疡面积、TNF-α、CRP、IL-8、唾液EGF低于对照组,CD^(4+)/CD^(8+)高于对照组,两组比较差异有统计学意义(P<0.05)。结论大蒜素软胶囊联合碘甘油治疗复发性口腔溃疡可迅速缓解患者症状,减轻炎性损伤,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Alltride Soft Capsules combined with iodine glycerol in treatment of recurrent oral ulcer. Methods Patients（104 cases） with recurrent oral ulcer in the Hospital of Shunyi District Beijing from October 2015 to October 2017 were randomly divided into control（52 cases） and treatment（52 cases） groups. Patients in the control group were used 1% Iodine Glycerol, three times daily. Patients in the treatment group were po administered with Alltride Soft Capsules, 1 grain/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of VAS score, ulcer area, TNF-α, CRP, IL-8, EGF, and CD^（4＋）/CD^（8＋） in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.8% and 94.2%, respectively, and there was difference between two groups（P〈0.05）. After treatment, VAS score, ulcer area, TNF-α, CRP, IL-8, and EGF in two groups were decreased, but CD^（4＋）/CD^（8＋） was increased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, VAS score, ulcer area, TNF-α, CRP, IL-8, and EGF in the treatment group were lower than those in the control group, but CD^（4＋）/CD^（8＋） was higher than that in the control group, and there was difference between two groups（P〈0.05）. Conclusions Alltride Soft Capsules combined with iodine glycerol has clinical curative effect in treatment of recurrent oral ulcer, and can relieve the symptoms of the patient quickly, also can reduce the inflammatory damage, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2018年第2期330-333,共4页
Drugs & Clinic
