摘要
目的探讨血清学指标结合干燥综合征疾病活动指数(ESSDAI)在原发性干燥综合征中的研究价值。方法选择2013年2月至2016年12月在该院诊治原发性干燥综合征患者68例作为干燥综合征组,选择同期在该院体检的健康者68例作为对照组,两组均进行ESSDAI评分与血清学指标检测[白细胞介素(IL)-27、IL-10、1,25(OH)2D],同时进行相关性分析。结果干燥综合征组的ESSDAI评分为(14.21±1.03)分,明显高于对照组的(1.87±0.45)分,差异有统计学意义(t=13.224,P<0.05)。干燥综合征组的血清IL-10、IL-27、1,25(OH)2D值分别为(158.33±32.19)pg/mL、(84.33±14.29)pg/mL和(8.42±2.49)ng/mL,对照组分别为(37.44±14.92)pg/mL、(23.11±1.94)pg/mL和(34.10±3.41)ng/mL,两组比较差异均有统计学意义(P<0.05)。Spearman相关分析显示干燥综合征患者的ESSDAI评分与IL-10、IL-27呈正相关(P<0.05),与1,25(OH)2D呈负相关(P<0.05)。多元Logistic回归分析结果显示IL-10、IL-27、1,25(OH)2D为影响ESSDAI评分的主要危险因素(P<0.05)。结论 ESSDAI为评估干燥综合征患者病情的常见指标,干燥综合征患者存在血清IL-10、IL-27、1,25(OH)2D表达异常情况,三者联合检测对于干燥综合征的诊断有一定的应用价值。
Objective To investigate the clinical value of serum index combined with EULAR Sjogren syndrome disease activity index(ESSDAI)in primary Sjogren syndrome(SS).Methods From February 2013 to December 2016,68 patients with SS in our hospital were selected as the SS group,and another 68 healthy people in our hospital physical examination were selected as the control group,two groups were tested with ESSDAI score and serum index[IL-27,IL-10,1,25(OH)_2 D],and the correlation analysis was conducted.ResultsThe ESSDAI score of SS group was 14.21±1.03,which was significantly higher than that of the control group of 1.87±0.45(t=13.224,P<0.05).The values of IL-10,IL-27,1,25(OH)_2 D in the sera of SS group were(158.33±32.19)pg/mL,(84.33±14.29)pg/mL and(8.42±2.49)ng/mL,in contrast to(37.44±14.92)pg/mL,(23.11±1.94)pg/mL and(34.10±3.41)ng/mL in the control group,respectively.There was statistically significant difference compared between the two groups(P<0.05).Spearman correlation analysis showed that the ESSDAI score were positively correlated with IL-10 and IL-27(P<0.05),and showed significant negatively correlated with 1,25(OH)_2 D(P<0.05).Multivariate logistic regression analysis showed that IL-10,IL-27,1,25(OH)_2 D were the main risk factors that affected ESSDAI score(P<0.05).Conclusion ESSDAI is a common index to evaluate the SS patients′condition.SS patients have obvious abnormal serum IL-10,IL-27 and 1,25(OH)_2 D levels which shows reciprocal interactions with ESSDAI score,which can be evaluated together for better applicable implications.
出处
《检验医学与临床》
CAS
2018年第5期577-579,582,共4页
Laboratory Medicine and Clinic
基金
北京市科技计划课题项目(z151100007879134)
