摘要
目的探讨白细胞介素-6(IL-6)、白三烯B4(LTB4)的联合检测对早期诊断儿童过敏性紫癜(HSP)的临床意义及其对预后的影响。方法选取2014年5月至2016年5月该院收治的HSP患儿68例,检测患儿发病早期及恢复早期血清中IL-6和LTB4水平,分析它们在HSP患儿早期诊断中的意义及对预后的影响。结果与对照组相比,儿童HSP急性期及恢复早期血清IL-6和LTB4浓度升高(P<0.05),且急性期浓度高于恢复早期(P<0.05)。急性期血清IL-6和LTB4水平越高,患儿出现肾损害的比例越大(P<0.05)。急性期血清IL-6和LTB4水平越高,患儿痊愈率更高(P<0.05),复发率更低(P<0.05)。二者联合检测诊断HSP的AUC为0.894,敏感度为0.811,优于IL-6和LTB4单独检测(P<0.05)。结论联合检测IL-6和LTB4对于HSP的早期诊断及预后判断具有重要临床意义。
Objective To investigate the clinical significance of interleukin-6（IL-6）and leukotriene B4（LTB4）in the early diagnosis of allergic purpura（HSP）in children and its effect on prognosis.Methods A total of 68 children with Henoch-Schonlein purpura enrolled in our hospital from May 2014 to May 2016 were selected.The levels of IL-6 and LTB4 in the early stage and early recovery stage of children were detected.The significance of early diagnosis and the impact on prognosis were analyzed.Results Compared with the control group,the levels of IL-6 and LTB4 in acute and early recovery stage of children with Henoch-Schonlein purpura were significantly higher（P〈0.05）,and those in the acute stage of children were higher than those in the early recovery stage（P〈0.05）.The higher the level of IL-6 and LTB4 in the serum,the greater the possibility of renal damage in patients,and the difference was statistically significant（P〈0.05）.The higher the level of serum IL-6 and LTB4,the higher the cure rate（P〈0.05）and the lower the recurrence rate（P〈0.05）.The AUC of the combined detection of HSP was 0.894 and the sensitivity was 0.811,which were better than those of IL-6 and LTB4（P〈0.05）.Conclusion Combined detection of IL-6 and LTB4 is of great clinical significance in the early diagnosis and prognosis of HSP.
出处
《国际检验医学杂志》
CAS
2018年第5期599-602,共4页
International Journal of Laboratory Medicine
