摘要
目的分析肺功能联合脑钠肽在慢性阻塞性肺疾病(COPD)治疗及预后评估中的作用。方法选取我院2019年8月—2020年3月收治的33例COPD患者,分别检查患者的肺功能与血气指标,检测其N末端B型利钠肽原(NT-proBNP)水平,根据GOLD指南中肺功能分级对患者进行分组,比较不同肺功能患者的上述指标水平,同时观察患者在治疗前后的各指标水平变化,分析NT-proBNP与肺功能、血气指标的相关性。结果不同肺功能分级患者的FEV1%pred、FEV1/FVC、PaO2、PaCO2与NT-proBNP比较具有统计学差异(P<0.05),随着患者肺功能降低其FEV1%pred、FEV1/FVC与PaO2均明显降低,PaCO2与NT-proBNP显著升高。患者在治疗后的FEV1%pred、FEV1/FVC与PaO2均明显高于治疗前,并且治疗后的PaCO2与NT-proBNP均明显低于治疗前,差异具有统计学意义(P<0.05)。NT-proBNP与FEV1%pred、FEV1/FVC、PaO2呈负相关性,与PaCO2呈正相关性。结论COPD患者NT-proBNP与肺功能、血气指标均具有相关性,针对性开展肺功能、血气指标联合NT-proBNP检验对疾病的治疗及预后评估具有重要的辅助作用。
Objective To analyze the role of pulmonary function combined with brain natriuretic peptide in the treatment and prognosis evaluation of chronic obstructive pulmonary disease(COPD).Methods 33 COPD patients in our hospital were selected from August 2019 to March 2020,their pulmonary function and blood gas indexes were examined,their N-terminal B-type natriuretic peptide(NT proBNP)levels were detected,and the patients were divided into groups according to the lung function classification in gold guidelines,and the above indexes of different lung function patients were compared.At the same time,the indexes of patients before and after treatment were observed The correlation of NT proBNP with pulmonary function and blood gas index was analyzed.Results FEV1%PRED,FEV1/FVC,PaO2,PaCO2 and NT proBNP of patients with different pulmonary function grades were statistically significant(P<0.05).With the decrease of pulmonary function,FEV1%PRED,FEV1/FVC and PaO2 were significantly reduced,PaCO2 and NT proBNP were significantly increased.After treatment,FEV1%PRED,FEV1/FVC and PaO2 were significantly higher than before treatment,and PaCO2 and NT proBNP were significantly lower than before treatment,the difference was statistically significant(P<0.05).NT proBNP was negatively correlated with FEV1%PRED,FEV1/FVC,PaO2,and positively correlated with PaCO2.Conclusion NT proBNP has correlation with lung function and blood gas index in COPD patients.It has a good effect on the treatment and prognosis of COPD patients by lung function,blood gas index and NT proBNP test.
作者
段林建
胡伶清
Duan Linjian;Hu Lingqing(The Traditional Chinese Medicine Hospital of Leping City,Leping,Jiangxi 333300)
出处
《基层医学论坛》
2020年第22期3109-3111,共3页
The Medical Forum
基金
景德镇市科技计划项目(2019ZSFZC066)。
关键词
慢性阻塞性肺疾病
肺功能
脑钠肽
治疗
预后评估
Chronic obstructive pulmonary disease
Pulmonary function
Brain natriuretic peptide
Treatment
Prognosis evaluation
