摘要
本文用尿药浓度法,研究了6名志愿者单剂量口服氟啶酸片、胶囊剂后的药物动力学。结果表明,氟啶酸片剂,胶囊剂具有相同的药物学特征及生物等效性。其药动学参数分别是:k(hr^(-1)):0.1048、0.1039;t1/2(hr):6.92,7.08;Au^(0-42)(mg):460.78,462.51;排泄率:76.80%,77.09%。氟啶酸片的相对生物利用度为99.62%。
The concentration of enoxacin in urine of six healthy chinese volunteers wasdetermined after the tablet or the capsule was orally given by single-dose. thepharmacokinetic parameters were calculated from the urine drug concentration cur-ves the result showed that the parameters of enoxacin tablet and capsule were K(hr^(-1)) 0. 1048,0.1039; t1/2(hr)6.92, 7.08; Au^(0-24)(mg)460. 78,462.51 and eliminative ra-te(cumulative)6.80%,77.09% respectively. the relative bioavailability of the tabletwas 99.6%
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第1期13-15,共3页
Chinese Journal of Hospital Pharmacy
关键词
氟啶酸
尿药浓度
药物动力学
Enoxacin
Drug levels in urine
pharmaeokineties
