摘要
目的 :探讨薄荷醇对环丙沙星粘膜吸收的影响。方法 :在双室透皮扩散装置上进行体外透粘膜吸收试验 ,计算渗透系数。结果 :环丙沙星的粘膜吸收随着浓度的增加 ,渗透系数有逐渐增加的趋势 ,而贮库效应降低更明显 ;使用薄荷醇后 ,环丙沙星的渗透系数均表现为下降趋势 ,尤其是 0 .2 %浓度薄荷醇组下降作用最明显 (P <0 .0 1 ) ,但其贮库效应却明显强于其它组。结论 :薄荷醇可明显降低环丙沙星粘膜吸收的渗透系数 ,加强其贮库效应。
AIM: To investigate the effect of l menthol on the absorption of ciprofloxacin (Cip) via the mucosa. METHODS: Mucosa absorption experiment and deposit effect were made on a two cells diffusion apparatus in vitro to calculate permeation coefficients. RESULTS: With increasing of the concentration of Cip, the permeation coefficient of mucosa absorption showed a increasing tendency, but deposit effect declined significantly. After using l menthol, the permeation coefficient of Cip showed a declining tendency. Especially at 0.2 percent concentration of l menthol, the decrease level was more obvious than other groups (P< 0.01 ), but its deposit effect was the largest. CONCLUSION: L Menthol could decrease permeation coefficient of mucosa absorption of Cip and obviously enhance deposit effect of Cip.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2002年第4期314-316,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家出入境检验检疫局资助课题 (№GDK0 2 2 0 0 1)
关键词
薄荷醇
环丙沙星
粘膜吸收
贮库效应
渗透系数
l menthol
ciprofloxacin
mucosa absorption
permeation coefficient
deposit effect
