摘要
目的探讨不同麻醉深度对宫颈癌手术老年患者术后早期认知功能的影响。方法拟行腹腔镜下宫颈癌根治术ASAⅡ~Ⅲ级患者78例,分为3组(每组26例),Ⅰ组:BIS=30~39,Ⅱ组:BIS=40~49,Ⅲ组:BIS=50~59。所有患者采用全凭静脉麻醉复合硬膜外神经阻滞。测定患者术前及术毕血清S100β蛋白的浓度,计算Da-jvO_2,CjvO_2及CERO_2,统计术后7天内POCD发生率。结果三组患者Da-jvO_2,CjvO_2及CERO_2术前与术毕均无明显差别(P>0.05);三组患者S100β蛋白术毕较术前含量明显增加(P<0.05),且Ⅰ组含量明显小于Ⅱ组和Ⅲ组(P<0.05);三组患者术后7天内POCD发生率比较,差异无统计学意义(P>0.05)。结论不同麻醉深度对宫颈癌手术老年患者术后早期认知功能无影响,深麻醉状态可以减轻患者脑损伤。
Objectives To investigate the effecs of different depths of anesthesia on postoperative cognitive in elderly patients undergoing radical surgery for cervical cancer. Methods Seventy-eight ASAⅡ - Ⅲ patients scheduled for laparoscopic radical hysterectomy were randomly divided into 3 groups（ 26 in each group） ： groupⅠ： BIS = 30 - 39,groupⅡ： BIS = 40 - 49,groupⅢ： BIS =50 - 59. The epidural combined intravenous anesthesia was applied in all groups. The serum levels of S100β protein were measured and Da-jvO2,CjvO2 and CERO2 were calculated at the time before operation and the end of operation respectively. Incidence of postoperative cognitive dysfunction（ POCD） were recorded within seven days after operation. Results In 3 groups,the Da-jvO2,CjvO2 and CERO2 were insignificant difference between before operation and the end of operation（ P〈0. 05）; Compared with the time before operation,the serum levels of S100β protein in 3 groups increased significantly at the end of operation（ P〈0. 05） and was lower in groupⅠthan groupⅡand groupⅢ（ P〈0. 05）; Incidence of POCD was insignificant difference in 3 groups（ P〈0. 05）. Conclusion Incidence of POCD for the elderly patients undergoing radical surgery for cervical cancer is influenced by the different depths of anesthesia and deep anesthesia can reduce cerebral injury.
出处
《中国老年保健医学》
2018年第1期49-51,共3页
Chinese Journal of Geriatric Care
关键词
麻醉深度
宫颈癌
老年患者
术后认知功能
depths of anesthesia, cervical cancer, aged, postoperative cognitive
