摘要
目的研究Narcotrend监测不同麻醉深度下对术后早期认知功能障碍(POCD)发生率的影响。方法系统检索PubMed、OVID、CNKI、CBM、万方数据库、维普数据库等,检索时间限制为建库至2016年12月31日,收集研究Narcotrend监测下不同麻醉深度对术后早期POCD发生率影响的随机对照实验,仔细阅读文献摘和全文,并对其参考文献进行追踪,对纳入文献进行数据提取及质量评价,采用Revman 5.3软件进行分析。结果最终有纳入8篇文献,共包括714例患者。Meta分析结果示:(1)深麻醉状态(NTS E0~E1)术后第1天POCD发生率明显低于常规麻醉状态(NTS D0~D1)(OR=0.21,95%CI0.13~0.35,P<0.000 01);(2)深麻醉状态(NTS E1)术后7天POCD发生率明显低于常规麻醉状态(NTSD0)(OR=0.45,95%CI 0.23~0.91,P=0.03);(3)常规麻醉状态中NTS D2术后7 d POCD发生率明显低于NTS D0(OR=0.42,95%CI 0.24~0.71,P=0.001)。结论 Narcotrend监测下深麻醉状态比常规麻醉状态对术后早期POCD发生率低。
Objective To investigate the effects of different depths of anesthesia on incidence of postopera-tive cognitive dysfunction（POCD）. Methods We systematically retrieved Pubmed,OVID,CNKI,CBM andWanfang database and VIP database for randomized controlled trials（RCTs）from inceptionto December 31 2016,comparing different depths of anesthesia for their impacts on incidence of early POCD. After data extraction andquality evaluation,Revman 5.3 software was used for statistical data analysis. Results A total of 714 patients in 8 eligible RCTs were identified. Results of meta-analysis were as follows.（1）Incidence of POCD of depth anesthesia（NTS = E0-E1）was lower than general anesthesia（NTS = D0-D1）1 d after surgery（OR = 0.21,95%CI 0.13 ~0.35,P 0.00001）.（2）Incidence of POCD of depth anesthesia（NTS = E1）was lower than general anesthesia（NTS = D0）7 d after surgery（OR = 0.45,95%CI 0.23 ~ 0.91,P = 0.03）.（3）Incidence of POCD of NTS = E1 was lower than NTS = D0 7d after surgery（OR = 0.42,95%CI 0.24 ~0.71,P = 0.001）. Conclusion Comparedwithgeneral anesthesia,depth anesthesia is associated with a lower incidence of early POCD.
出处
《实用医学杂志》
CAS
北大核心
2017年第20期3467-3471,共5页
The Journal of Practical Medicine
基金
广东省高等教育学会高等教育科学研究"十三五"规划课题项目(编号:16GYB021)
广州市荔湾区2016科技计划项目(编号:2016080068)
