摘要
目的:评价盐酸达泊西汀治疗早泄患者的疗效及焦虑抑郁情绪的影响。方法:选取2014年6月至2016年7月于我院就诊的早泄患者120例,随机分为处理组和对照组,处理组为使用盐酸达泊西汀30mg每天1次,共使用8周,对照组使用复方利多卡因乳膏,对比两组患者的阴道内射精潜伏期(IELT),使用早泄量表(PEP)对比两组患者的早泄情况,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)比较两组患者治疗前后的焦虑抑郁改善情况。结果:两组患者在治疗前的IELT比较差异无统计学意义(t=0.053,P=0.958),治疗4周后,处理组IELT和对照组比较差异无统计学意义(t=0.870,P=0.386),治疗8周后,处理组的IELT显著高于对照组,差异具有统计学意义(t=5.706,P<0.01),治疗8周后,处理组患者的射精控制能力、性生活满意度、早泄相关苦恼、早泄相关伴侣间沟通困难4项评分均显著高于对照组,差异具有统计学意义(P<0.05),治疗8周后,处理组患者的SAS评分和SDS评分显著低于对照组,差异具有统计学意义(P<0.01)。结论:盐酸达泊西汀可提高早泄男性阴道内射精潜伏期,显著改善早泄相关症状,也能缓解患者的焦虑和抑郁情绪。
Objectives： To evaluate the influence of dapoxetine in the treatment of premature ejaculation（ PE） on anxiety and depression. Methods： From June 2014 to July 2016,120 patients with PE were selected in our hospital,which randomly divided into treatment group and control group. The treatment group received dapoxetine of 30 mg once daily for eight weeks,and the control group received compound lidocaine cream. The intra-vaginal ejaculation latency time（ IELT） of two groups was compared. The premature ejaculation scale（ PEP） was used to evaluate the level of PE in the two groups. The self-evaluation of anxiety scale（ SAS）,and the depression self-rating scale（ SDS） were used to compare the anxiety and depression in two groups between before and after treatment. Results： The IELT of two groups before treatment had no significant difference（ t = 0. 053,P = 0. 053）.After 4 weeks of treatment,IELT in treatment group and control group had no significant difference（ t = 0. 870,P =0. 870）. After 8 weeks of treatment,the treatment group had significantly higher IELT than control group（ t =5. 706,P 0. 01）. The scores of ejaculations control ability,sexual satisfaction,PE related distress and PE partner communication difficulties in treatment group were significantly higher than these of control group,with significant differences（ P 0. 05）. After 8 weeks of treatment,SAS score and SDS score in treatment group were significantly lower than these in control group,with statistically significant difference（ P 0. 01）. Conclusion： Dapoxetine can improve the intra-vaginal ejaculation latency time of patients with PE,and significantly improve the symptoms,which also can relieve patients＇ anxiety and depression.
出处
《中国性科学》
2018年第1期24-27,共4页
Chinese Journal of Human Sexuality
基金
湖北省科技厅项目成果(ZRZ2015000037)
关键词
盐酸达泊西汀
早泄
焦虑
抑郁
阴道内射精潜伏期
Dapoxetine
Premature ejaculation （PE）
Anxiety
Depression
Intra -vaginal ejaculation la-tency time
