摘要
细胞外信号调节激酶(extracellular regulated protein kinases,ERK)是含有丝氨酸/苏氨酸残基的蛋白质激酶,目前发现ERK1~ERK5共5个亚族,广泛存在于细胞浆内。ERK是丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)信号转导系统组成部分之一,ERK信号通路可通过磷酸化多种底物蛋白在细胞生长、分化、应激及凋亡中起重要作用。本文就ERK信号通路在心肌细胞、神经细胞、肿瘤细胞及淋巴细胞中调节作用的研究进展作一综述。
Extracellular regulated protein kinase（ERK） is an important member of mitogen activated protein kinase family, which contains serine/threonine residues. At present, there are five subgroups of ERK, i. e. ERK1 - EKR5, which exist in cytoplasm. ERK signaling pathway plays an important role in cell growth, differentiation, stress and apoptosis through phosphorylation of a variety of substrate proteins. This paper reviews the progress in study on regulatory role of ERK signaling pathway in cardiac muscle cells, nerve cells, tumor cells and lymphocytes.
出处
《中国生物制品学杂志》
CAS
CSCD
2018年第1期93-96,共4页
Chinese Journal of Biologicals
关键词
细胞外信号调节激酶
心肌细胞
神经细胞
肿瘤细胞
淋巴细胞
Extracellular regulated protein kinase
Cardiac muscle cells
Nerve cells
Tumor cells
Lymphocytes
