摘要
目的分析子痫前期孕妇胎盘中脂联素、金属蛋白酶-9(MMP-9)、胎盘因子水平的表达与妊娠结局的相关性,为子痫前期孕妇终止妊娠时机决策提供参考。方法选我院收治的中晚期子痫前期孕妇82例设为研究组,选取同期正常妊娠的中晚期孕妇82例为对照组,两组孕妇娩出胎盘后,获取胎盘组织,进行组化染色后,采用实时荧光定量逆转录聚合酶链式反应技术分析所有受试者胎盘组织中的脂联素、MMP-9、胎盘生长因子的而表达情况及妊娠结局,并进行组间比较。对研究组患者的妊娠结局进行统计,按照妊娠结局分为妊娠结局不良组(25例)和正常组(57例),比较不同妊娠结局子痫前期孕妇胎盘组织中的脂联素、MMP-9、胎盘生长因子表达情况及妊娠结局情况。采用pearson分析脂联素、MMP-9、胎盘生长因子与妊娠结局见的相关性。结果研究组孕妇围产儿死亡率、入NICU率、呼吸系统窘迫率、宫内生长受限率均明显高于对照组(P<0.05),出生后Apgar评分、出生孕周、出生体质量、胎盘重量均明显低于对照组(P<0.05)。胎盘中脂联素明显高于对照组(P<0.05),MMP-9和胎盘生长因子均明显低于最爱好组(P<0.05)。研究组孕妇中妊娠结局不良组孕妇的胎盘脂联素、MMP-9、胎盘生长因子与妊娠结局良好组差异无统计学意义(P>0.05)。研究组孕妇胎盘脂联素与妊娠结局不良呈高度正相关(r=0.783),MMP-9、生长因子与妊娠结局不良呈高度负相关(r=-0.694、-0.792)。结论中晚期子痫前期孕妇胎盘脂联素、MMP-9、生长因子与妊娠结局有较强的相关性,在期待治疗期间监测上述指标,可在一定程度上预测妊娠结局,为孕妇终止妊娠的决策提供指导,提高围生儿安全和健康水平。
Objective：To analyze the correlation between the expression of adiponectin,metalloproteinase-9（MMP-9）and placental factor in the placenta of preeclampsia pregnant women and the outcome of pregnancy,and to provide reference for the decision of termination of pregnancy in pregnant women with preeclampsia.Methods：82 cases of middle and late preeclampsia were selected as the study group.82 cases of middle and late pregnant women with normal pregnancy were selected as the control group.After the placenta was delivered to the placenta,the placenta was obtained and stained The expression of adiponectin,MMP-9 and placental growth factor in placenta of all subjects was analyzed by real-time fluorescence quantitative reverse transcription polymerase chain reaction（RT-PCR）,and the results were compared between groups.（25 cases）and normal group（57 cases）were compared according to the outcome of the pregnancy group.The expression of adiponectin,MMP-9 in the placenta of pregnant women with preeclampsia was compared,Placental growth factor expression and pregnancy outcome.The correlation between adiponectin,MMP-9,placental growth factor and pregnancy outcome was analyzed by pearson analysis.Results：The perinatal mortality rate,NICU rate,respiratory distress rate and intrauterine growth restriction rate were significantly higher in the study group than in the control group（P〈0.05）.Apgar score,birth gestational age,birth weight,Placental weight were significantly lower than the control group（P〈0.05）.Placenta adiponectin was significantly higher than the control group（P〈0.05）,MMP-9 and placental growth factor were significantly lower than the favorite rent（P〈0.05）.There was no significant difference in placental adiponectin,MMP-9,placental growth factor and pregnancy outcome in pregnant women with poor pregnancy outcome group（P〈0.05）.There was a high positive correlation between placental adiponectin and pregnancy outcome（r=0.783）.MMP-9 and growth factor were negatively correlated with pregnancy outcome（r=-0.694,-0.792）.Conclusion：Adiponectin,MMP-9 and growth factor in placenta of middle and late preeclampsia have strong correlation with pregnancy outcome.The above indicators can be monitored during the expectation of treatment,and the pregnancy outcome can be predicted to a certain extent.To provide guidance to improve the safety and health of perinatal children.
出处
《中国优生与遗传杂志》
2018年第1期9-12,共4页
Chinese Journal of Birth Health & Heredity
