摘要
目的：探讨子痫前期患者血清脂联素水平和胎盘基质金属蛋白酶-9（MMP-9）的表达情况及二者关系。方法：选择2007年8月～2012年8月入住我院及深圳市第七人民医院的90例经临床诊断为子痫前期患者作为观察组，另外选择同期收治的90例正常妊娠妇女作为对照组，测定两组血清脂联素水平，胎盘娩出之后取胎盘组织进行固定、切片，采用免疫组化法检测胎盘MMP-9的阳性表达率。结果：随着子痫病情的加重，患者血清脂联素水平逐渐下降，且轻度和重度子痫前期患者血清脂联素水平均明显低于对照组，差异有统计学意义（P〈0．05）；随着子痫病情的加重，患者MMP-9阳性表达率逐渐下降，且轻度和重度子痫前期患者MMP-9阳性表达率与对照组相比，差异具有统计学意义（P〈0．05）；子痫前期患者血清脂联素水平与MMP-9的阳性表达率呈正相关性关系（r=0．75，P〈0．01）。结论：子痫前期患者血清脂联素水平与MMP-9阳性表达率较正常妊娠妇女出现显著降低，且随着病情的加重，上述两个指标值明显降低。
Objective. To investigate the relationship between serum adiponectin levels and placen- tal matrix metalloproteinase-9 （MMP-9） expression in patients with pre-eclampsia. Methods： A total of 120 cases with clinical diagnosis of pre-eclampsia admitted during 2007.08-2012.08 were selected as the observation group, 120 normal pregnant women during same period were selected as control group. Blood serum adiponectin levels were measured, and placental tissues were taken after expulsion of the placenta. Then these tissues were fixed and sliced. Placental MMP-9 was measured by immunohistochemical method. Results： As pre-eclampsia condition was aggravated, serum adiponectin levels were gradually declined, serum adiponectin levels of pre-eclampsia patients were significantly lower than that of control group （P〈 0.05） ; MMP-9 was positively correlated with serum lipid adiponectin in patients with pre-eclampsia （r= 0.75, P〈0.01）. Conclusions： Serum adiponectin levels and MMP-9 positive expression in patients with pre-eclampsia are significantly lower than that of normal pregnant women, and these two indicators decline as the disease is worsened.
出处
《海南医学院学报》
CAS
2013年第12期1644-1646,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210888)~~
