摘要
目的观察益生菌联合抚触对喂养不耐受早产儿治疗效果及血清胆红素、生长发育的影响研究。方法将76例喂养不耐受早产儿随机分为2组,对照组30例行小剂量红霉素治疗,干预组46例加微生物制剂联合抚触治疗。比较2组症状消失时间、每日进奶量、进奶增加量,达到完全肠道营养时间、体重开始增长时间、恢复出生体重时间、住院时间,对其并发症发生情况进行记录统计分析,检测2组治疗前后血清胆红素、前白蛋白、血红蛋白水平。结果干预组患儿腹胀、呕吐、胃潴留消失症状更早,每日进奶量、进奶增加量多,达到完全肠道营养时间、体重开始增长时间、恢复出生体重时间早,住院时间短,便秘、低血糖、病理性黄疸、NEC发生率低(P<0.05),患儿满月时治疗组患儿腹围及体重增长明显(P<0.05)。2组治疗后血清直接胆红素及间接胆红素均降低,前白蛋白及血红蛋白明显升高,且2组组间比较差异有统计学意义(P<0.05)。结论双歧三联活菌联合抚触治疗可以加快胃排空,促进胃肠功能发育、成熟,尽早建立胃肠营养,改善喂养不耐受,降低血清胆红素的水平,进而促进早产儿的生长发育。
Objective To observe the effects of probiotics combined with touching on curative effects,serum bilirubin,growth and development of premature infants with feeding intolerance. Methods Seventy-six premature infants with feeding intolerance were randomly divided into two groups. The 30 patients in control group were treated by low dose erythromycin,however,the 46 patients in intervention group were treated by probiotics combined with touching. The disappearance time of symptoms,everyday amount of milk intake,the increase amount of milk intake,the time up to complete intestinal nutrition,the start time of weight gain,the time of birth weight recovery,the length of staying in hospital,incidence of complications were observed and compared between two groups. Moreover the serum levels of bilirubin,prealbumin and hemoglobin were detected before and after treatment in both groups. Results The symptoms of abdominal distension,vomiting,and gastric retention in intervention group were disappeared more early,moreover,everyday amount of milk intake and the increase amount of milk intake were more than those in control group. The time up to complete intestinal nutrition,the start time of weight gain and the time of birth weight recovery in intervention group were earlier,however,the length of staying in hospital was shorter,moreover,the incidence rates of constipation,hypoglycemia,pathologic jaundice and NEC were significantly lower than those in control group（ P 〈0. 05）. The abdominal circumference and body weight in full month were significantly increased in intervention group（ P 〈0. 05）. After treatment,the serum levels of bilirubin and indirect bilirubin were decreased,the levels of prealbumin and hemoglobin were obviously increased in both groups,moreover,there were significant differences between two groups（ P 〈0. 05）. Conclusion The birid triple viable combined with touching therapy can speed up gastric emptying,promote gastrointestinal function development and maturity,establish early gastrointestinal nutrition,improve feeding intolerance,lower serum levels of bilirubin,so as to promote the growth and development of preterm infants.
出处
《河北医药》
CAS
2018年第3期347-351,共5页
Hebei Medical Journal
基金
唐山市科学技术研究与发展指导计划项目(编号:13130279a)
关键词
早产儿
血清胆红素
益生菌
premature infants
serum bilirubin
probiotils
