摘要
二甲双胍是治疗糖尿病的一线药物,除具有降糖作用外,还有抗肿瘤的作用。但是否可以降低2型糖尿病患者恶性肿瘤的发病率和病死率尚存在争议。二甲双胍抗肿瘤作用的机制目前发现可能包括激活腺苷酸活化蛋白激酶(AMPK)途径、诱导细胞周期停滞、促进细胞凋亡、抑制肿瘤细胞侵袭转移、抑制炎症反应及杀灭肿瘤干细胞等。该文就二甲双胍抗肿瘤作用的相关机制和临床研究予以综述。
Metformin is a first-line drug for the treatment of diabetes.It has not only hypoglycemic effect but also an anti-tumor effect.However,there is still controversy over whether it reduces cancer incidence and mortality in patients with type 2 diabetes.The antitumor mechanisms of metformin may include activating adenosine monophosphate activated protein kinase(AMPK) pathway,inducing cell cycle arrest,promoting apoptosis,inhibiting invasion and metastasis of tumor cells,inhibiting the inflammatory response and killing tumor stem cells.In this paper,we reviewed the mechanisms and clinical studies on the anti-tumor effects of metformin.
出处
《安徽医药》
CAS
2018年第3期402-406,共5页
Anhui Medical and Pharmaceutical Journal
基金
合肥市第五周期医学重点专科建设项目(合卫科教[2016]256)
