摘要
目的调查北京城镇中老年人25-羟维生素D_3、甲状旁腺素、骨钙素与骨密度的相关性。方法采用美国DTX-200型双能X线骨密度仪,检测北京大兴区成年男性428例、女性778例的非优势前臂桡骨远端1/3处的骨密度。采用电化学发光免疫分析法测定25-羟维生素D_3[25(OH)D_3]、甲状旁腺素、血清骨钙素N端中分子片段(N-terminal-midfragment of osteocalcin,N-MID)。采用SPSS24.0统计学软件分析不同性别、年龄段组25(OH)D_3、甲状旁腺素、血清骨钙素N端中分子片段、非优势前臂桡骨远端1/3处的骨密度水平。结果 25(OH)D_3水平在不同性别间存在显著差异(P<0.01);甲状旁腺素性别间无统计学差异(P>0.05);血清骨钙素N端中分子片段50~69岁年龄段不同性别间存在显著差异(P<0.01);非优势手臂桡骨远端1/3处骨密度性别间无统计学差异(P>0.05);非优势手臂桡骨远端1/3处骨密度与25-羟维生素D_3[25(OH)D_3]、甲状旁腺素呈正相关,非优势手臂桡骨远端1/3处骨密度与年龄、血清骨钙素N端中分子片段呈负相关。结论北京中老年人女性普遍缺乏维生素D。25-羟维生素D_3[25(OH)D_3]、甲状旁腺素、血清骨钙素N端中分子片段与骨密度可综合评价骨质疏松症各阶段。
Objective To investigate the correlation between 25-hydroxyvitamin D3125（OH）D3], parathyroid hormone （PTH）, osteocalcin and bone mineral density（BMD）. Methods The bone density of the distal 1/3 of non-dominant forearm radius in 428 males and 778 females from Daxing District of Beijlng were measured by the United States DTX-200 du- al-energy X-ray absorptiometry. 25 （OH）D3, PTH and serum N-terminal-mid fi＇agment of osteocalcin （N-MID） were measured by electrical chemiluminescent immunoassay（ECLIA）. Difference in 25（OH）D3, PTH, serum N-MID and BMD between gender and age groups were analyzed using SPSS（version 24.0）. Results The difference in 25（OH）D3 level be- tween gender was significant（P〈0.01）. No statistical difference between gender was found in [rFH（P〉O.05）. There was significant gender difference in serum N-MID between gender during 50-69 age group（P〈0.01）. While there was no gender difference in BMD of the distal 1/3 of non-dominant forearm radius（P〉0.05）. The BMD at 1/3 of the distal radius of non-dominant arm was positively correlated with 25 （OH）D3 and PTH, while was negatively correlated with age and serum N-MID. Conclusion There is a general lack of vitamin D in middle-aged and elderly female in Beijing. 25 （OH）D3, PTH, serum N-MID and BMD can provide comprehensive evaluation of all stages of osteoporosis.
出处
《中国现代医生》
2018年第2期4-7,共4页
China Modern Doctor
基金
北京市科技计划课题(Z151100004015233)
