摘要
目的:制备芒柄花素(FMN)包合物脂质体,并评价其质量。方法:以薄膜分散法制备FMN包合物脂质体,考察所制脂质体的外观形态、粒径、Zeta电位、包封率以及体外释放行为。结果:所制FMN包合物脂质体的粒径为(255.34±12.87)nm、Zeta电位为(25.32±3.51)m V、包封率为(81.63±0.79)%(n=3)、24 h的累积释放度为56.12%。结论:本方法成功制得具有良好缓释效果的FMN包合物脂质体,且质量符合相关标准。
OBJECTIVE：To prepare Formononetin（FMN）inclusion compound liposome and evaluate its quality. METHODS：FMN inclusion compound liposome was prepared by film dispersion method. The morphology,particle size,Zeta potential,encapsulation efficiency and in vitro release properties were studied. RESULTS：The particle size,Zeta potential and encapsulation efficiency of prepared FMN inclusion compound liposome were（255.34 ± 12.87） nm,（25.32 ± 3.51） m V,（81.63 ± 0.79）%,respectively（n=3）. The 24 h accumulative release rate of prepared FMN inclusion compound liposome was 56.12%.CONCLUSIONS：FMN inclusion compound liposome with good sustained-release effect is prepared successfully and in line with related quality standard.
出处
《中国药房》
CAS
北大核心
2018年第3期303-306,共4页
China Pharmacy
基金
国家自然科学基金资助项目(No.81403111)
关键词
芒柄花素
包合物
脂质体
质量评价
Formononetin
Inclusion compound
Liposome
Quality evaluation
