摘要
目的观察注射用青蒿琥酯和青蒿琥酯-盐酸阿莫地喹片序贯治疗南苏丹恶性疟疾的临床效果。方法选择2016年4月至2017年7月南苏丹朱巴中国维和步兵营一级医院收治的恶性疟疾患者31例,均肌肉注射青蒿琥酯注射液(首剂120 mg,4 h后再次肌肉注射60 mg,然后每日肌肉注射60 mg)1~3 d,体温恢复至正常范围后24、48、72 h口服青蒿琥酯-盐酸阿莫地喹片2片,共6片;观察治疗效果。结果 31例疟疾患者的总治愈率为100.0%(31/31),其中3 d治愈率为90.3%(28/31),3~6 d治愈率为9.7%(3/31)。4例(12.9%)患者发生恶心、呕吐、食欲减退、腹胀、腹泻、头晕等轻度不良反应,治疗结束后均自行消失。结论注射用青蒿琥酯和青蒿琥酯-盐酸阿莫地喹片序贯治疗南苏丹恶性疟疾疗效显著,且患者耐受性好。
Objective To investigate the efficacy of sequential administration of artesunate injection and artesunateamodiaquine tablets for the treatment of falciparum malaria in South Sudan. Methods The clinical data of thirty-one patients with falciparum malaria in Level One Hospital of the Chinese Peacekeeping Infantry Battalion from April 2016 to July 2017 were analyzed retrospectively. All patients were administered artesunate injection( 120 mg for the first time,60 mg 4 h later,then 60 mg once daily) by intramscular injection for 1-3 d. The patients took orally artesunate-amodiaquine tablets( 2 tablets) at 24,48,72 h after the body temperature restored to normal( totally 6 tablets). The efficacy of this sequential treatment for falciparum malaria was observed. Results The total cure rate of the 31 falciparum malaria patients was 100. 0%( 31/31);the cure rate of patients after 3 days treatment was 90. 3%( 28/31) and the cure rate of patients after 3-6 days treatment was 9. 7%( 3/31). Mild side effects,such as nausea,vomiting,anorexia,abdominal distension,diarrhea or dizziness were observed in 4 patients( 12. 9%) and all these symptoms disappeared after the end of treatment. Conclusion The sequential administration of artesunate injection and artesunate-amodiaquine tablets has optimal curative efficacy on falciparum malaria in South Sudan,and the tolerance is well.
出处
《新乡医学院学报》
CAS
2018年第2期118-121,共4页
Journal of Xinxiang Medical University
基金
河南省科技厅科技攻关项目(编号:142102310045)
