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TC新辅助化疗对Her-2阴性Luminal B型乳腺癌的疗效观察 被引量:1

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摘要 目的观察分析TC新辅助化疗方案(多西他赛+环磷酰胺)对Her-2阴性Luminal B型乳腺癌的疗效及安全性评价。方法选取2013年1月至2016年12月郑州大学第一附属医院收治的41例Her-2阴性Luminal B型乳腺癌患者,均接受TC新辅助化疗2~4个周期(21 d为1个周期),观察其治疗效果及毒副反应发生情况。结果化疗后,41例患者中,病理完全缓解(p CR)2例,部分缓解(PR)26例,稳定(SD)13例,总有效率为68.3%。其中浸润性导管癌21例,总有效率为66.7%;浸润性小叶癌12例,总有效率为75.0%;其他类型乳腺癌8例,总有效率为62.5%。化疗期间,出现中性粒细胞减少32例,恶心、呕吐32例,腹泻、便秘10例,脱发39例,肝功能损害9例,经对症处理,患者均能耐受。结论 TC新辅助方案对Her-2阴性Luminal B型乳腺癌患者近期疗效显著,安全可靠。
出处 《河南医学研究》 CAS 2017年第24期4447-4448,共2页 Henan Medical Research
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