摘要
目的探讨青少年突发性聋发病与血液流变学变化的相关性及其临床意义。方法本院治疗的40例青少年突发性聋患者作为观察组,选取同期健康体检者40例作为对照组。观察组患者给予前列地尔+舒血宁治疗,疗程2周。治疗前后均进行血液流变学检测。以对照组相关指标为基础,观察比较患者疗效与血液流变学变化趋势的相关性及其临床意义。结果经系统治疗后,本组患者痊愈10例(25%),显效8例(20%),有效11例(27.5%),总有效率72.5%。这些患者入院时全血黏度(低切、中切、高切)、血浆黏度、红细胞聚集指数、红细胞电泳指数均明显高于健康对照组(P<0.05);这些指标于治疗后明显改善,治疗前后差异比较有统计学意义(P<0.05)。结论血液流变学指标变化与青少年突发性聋患者的年龄呈正相关,涉及其发病过程。
Objective To investigate the pathogenesis association of sudden hearing loss with changes in the indexes of hemorrheology and their clinical implications among adolescents based on a clinical trial. Methods Included in this trial were 40 adolescent cases with sudden hearing loss treated in our hospital as observation group（OG）, with another 40 healthy persons as control group （CG）. The cases in OG were given a combined therapy with progeria and hematine lasted for two weeks. Before and after the therapy, hemorrheology was determined among all these cases as well as in controls. Then, the changes in the indexes of hemorrheology were analyzed in a comparative way with that of controls to explore the association of therapeutic effect on hearing loss of cases with hemorrheological changing tendency. Results Among these 40 cases, 10 （25.0%） were cured, 8 （20.0%） significantly effective, 11 （27.5%） effective, with a total effective rate of 72.5% following the systematic treatment. The patients in OG showed obviously elevated hemorrheological indicators as whole blood viscosity （low cut, medium cut and high cut）, plasma viscosity, erythrocyte aggregation index and erythrocyte electrophoresis index than that of controls before the treatment, with markedly statistical significance in their differences when compared with those in CG （P 〈0.05）. After the therapy, these abnormally elevated hemorrheological indicators were significantly improved, with significantly statistical significance in the differences when compared with those before treatment （P〈0.05）. Conclusion There is a positive correlation present between the changes in hemorrheological indicators and age of adolescent cases with sudden hearing loss when occurring.
出处
《中国中西医结合耳鼻咽喉科杂志》
2017年第6期401-404,共4页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
广东佛山市国家中医药管理局重点专科培育项目(编号:Fspy2-2015008)
广东佛山市高水平医学重点专科(编号:FSGSPZD135022)
广东佛山市卫计局科研项目(编号:20160136)
关键词
突发性聋
青少年患者
血液流变学
相关性
临床意义
Sudden hearing loss
Adolescent patients
Hemorheology
Association
Clinical implications
