摘要
目的研究分析锌、维生素D与钙联合治疗婴幼儿佝偻病的效果与相关生化指标变化的情况。方法选择在本院进行治疗的佝偻病婴幼儿(63例)作为此次研究分析的对象,并按照随机分配的原则将其分设为实验组及对照组。其中,实验组的例数为32例,给予维生素D及葡萄糖酸锌口服液、碳酸钙进行联合治疗,对照组的例数为31例,仅给予碳酸钙、维生素D3进行治疗,对比分析两组的临床效果及相关指标变化的情况。结果对照组于治疗后的BALP、BGP、25-OHD_3、DPD、Ca^(2+)含量的升高幅度均明显比实验组低(P<0.05);给予全部患儿为期12个月的随访,对照组的25-OHD_3、骨密度、BALP的水平均显著低于实验组(P<0.05);对照组佝偻病的临床复发率显著高于实验组(P<0.05);两组患儿于治疗后均出现了不良反应,但停药后自行消失,两组比较差异无统计学意义。结论给予佝偻病患儿应用锌、维生素D与钙联合进行治疗,可取得较为显著的临床效果,建议推广。
Objective To study the effect of zinc,vitamin D and calcium combined treatment on rickets in infants and the changes of related biochemical indexes.Methods Infants and young children with rickets in our hospital(63 cases) were selected as the objects of the study,and they were divided into the experimental group and the control group according to the principle of random allocation.Among them,the number of cases in the experimental group for 32 cases,treated with vitamin D and zinc gluconate,calcium carbonate combined treatment,the control group the number of cases was 31 cases,were treated only with calcium carbonate,vitamin D_3,comparative analysis on the changes of the clinical effects of two groups and the related indexes of the situation.Results The increase in the control group after treatment BALP,BGP,25-OHD_3,DPD,Ca^(2+) content was significantly lower than the experimental group(P<0.05); give all children were followed up for 12 months,control group 25-OHD_3,bone mineral density,BALP levels were significantly lower than the experimental group(P<0.05); the control group of rickets clinical relapse rate was significantly higher than the experimental group(P<0.05); the two groups after treatment had adverse reactions,but disappear after treatment,the two groups had no statistically significant difference.Conclusion The application of zinc,vitamin D and calcium in the treatment of rickets in children can achieve more significant clinical effect,it is recommended to promote.
出处
《当代医学》
2018年第3期35-37,共3页
Contemporary Medicine
