摘要
目的系统评价外用米诺地尔与口服非那雄胺联合治疗男性雄激素性秃发(AGA)的疗效和安全性。方法计算机检索Pub Med、EMbase、Cochrane Library、CBM、WF、CNKI和VIP数据库建库至2017年3月20日关于外用米诺地尔与口服非那雄胺联合治疗AGA的随机对照试验(RCT)和临床对照试验(CCT),并对全部纳入文献的参考文献进行追溯,由两位评价者根据纳入排除标准独立对文献进行筛选和评价,然后进行数据提取。运用Rev Man5.3软件进行统计分析。结果共纳入7篇文献,共1786例患者,经Meta分析表明:治疗3个月后,联合治疗组对AGA疗效优于米诺地尔组(OR=1.95,95%CI:1.37~2.76,P=0.0002)和非那雄胺组(OR=2.30,95%CI:1.64~3.23,P<0.000 01)。治疗6个月后,联合治疗组对AGA疗效优于米诺地尔组(OR=2.20,95%CI:1.26~3.84,P=0.005)和非那雄胺组(OR=2.50,95%CI:1.46~4.30,P=0.0009)。治疗12个月后,联合治疗组对AGA疗效优于米诺地尔组(OR=6.83,95%CI:2.92~15.99,P<0.000 01)和非那雄胺组(OR=2.77,95%CI:1.77~4.32,P<0.000 01)。各组均未发生严重不良反应。结论外用米诺地尔与口服非那雄胺联合治疗效果显著,安全性较好。
Objective To review systematically the curative effect and safety of combined treatment with oral Finasteride and topical Minoxidil in male androgenetic alopeeia （AGA）. Methods The databases of PubMed, EMbase, Cochrane Library, CBM, WanFang, CNKI and VIP were retrieved for collecting RCT and CCT about combined treatment with oral Finasteride and topical Minoxidil in AGA before March 20th 2017, and reference lists were also searched. According to the inclusion and exclusion criteria, two reviewers screened and assessed independently the potential studies, and then the data was extracted. The data was given a Meta-analysis by using RevMan 5.3 software. Results Seven study articles were included, involving 1786 patients. The Meta-analysis showed： after 3 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group （OR = 1.95, 95%CI： 1.37-2.76, P = 0.0002） and the Finasteride group （OR = 2.30, 95%CI： 1.64-3.23, P 〈 0.000 01）. After 6 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group （OR = 2.20, 95%CI： 1,26-3.84, P = 0.005） and the Finasteride group （OR = 2.50, 95%CI： 1.46-4.30, P = 0.0009）. After 12 months of treat rnent, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group （OR = 6.83, 95%CI： 2.92-15.99, P 〈 0.000 01） and the Finasteride group （OR = 2.77, 95%CI： 1.77-4.32, P 〈 0.000 01）. There were no serious adverse reactions in each group. Conclusion The combination treatment of Finasteride and topical Minoxidil has significant curative effect, and the safety is good.
出处
《中国医药导报》
CAS
2018年第1期109-113,149,共6页
China Medical Herald
