摘要
目的:研究P504S/AMACR在穿刺前列腺癌标本中的表达及其临床意义。方法:应用免疫组化二步法检测穿刺前列腺癌标本中P504S/AMACR的表达情况,并分析其在肿瘤组织中的表达与各临床病理因素的相关性。结果:P504S/AMACR在前列腺高级别上皮内瘤变(HGPIN)和前列腺癌组织中的表达显著高于癌旁前列腺组织,P504S/AMACR的高表达与患者高Gleason评分(P<0.01)及骨转移之间(P<0.01)存在显著相关性。但其表达与患者年龄、术前总PSA、临床分期之间均无显著相关性(P>0.05)。结论:P504S/AMACR在不同前列腺组织中的表达强度不同,其表达强度与前列腺癌Gleason评分和骨转移明显相关。
Objective：To investigate the expression and significance of P504S/AMACR protein in prostate cancer.Methods：We used immunohistochemistry to study the expression of the P504S/AMACR protein in prostate cancer.The P504S/AMACR staining scores were compared with several clinicopathological parameters.Results：Compared with the paracancerous tissues,the expression of P504S/AMACR protein was increased in prostate cancer and HGPIN tissues.The expression of P504S/AMACR protein was associated with high Gleason scores （P〈0.01） and bone metastasis （P〈0.01）.However,There was no statistically significant association between P504S/AMACR protein expression and age,total prostate specific antigen （PSA） level and clinical stage （P〉0.05）.Conclusion：The expression of P504S/AMACR protein was associated with high Gleason scores and bone metastasis of the cancer.
出处
《现代肿瘤医学》
CAS
2018年第3期423-426,共4页
Journal of Modern Oncology
